Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma

Hue H. Luu; Lan Zhou; Rex C. Haydon; Andrea T. Deyrup; Anthony G. Montag; Dezheng Huo; Robert Heck; Claus W. Heizmann; Terrance D. Peabody; Michael A. Simon; Tong Chuan He

doi:10.1016/j.canlet.2005.02.015

Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma

Hue H. Luu, Lan Zhou, Rex C. Haydon, Andrea T. Deyrup, Anthony G. Montag, Dezheng Huo, Robert Heck, Claus W. Heizmann, Terrance D. Peabody, Michael A. Simon, Tong Chuan He^*

^*Corresponding author for this work

Orthopaedic Surgery

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

While most osteosarcoma patients have metastatic or micrometastatic lesions, less than 15% of them have clinically detectable metastatic diseases at presentation. To identify potential markers that may predict osteosarcoma metastasis, we analyzed the expression of S100A6 in 50 osteosarcoma cases and found that 84% of the analyzed specimens stained positive for S100A6. There is a trend towards decreased clinically evident metastasis with increased S100A6 staining. Overexpression of S100A6 in osteosarcoma cells decreases cell motility and anchorage independent growth on collagen gels. Our findings provide evidence that, while S100A6 is commonly overexpressed in human osteosarcoma, loss of its expression correlates with a metastatic phenotype.

Original language	English (US)
Pages (from-to)	135-148
Number of pages	14
Journal	Cancer Letters
Volume	229
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2005.02.015
State	Published - Nov 8 2005

Funding

We would like to thank the staff at The University of Chicago Cancer Registry for their valuable assistance. This work was supported in part by research grants from The Brinson Foundation, the Orthopedic Research and Education Foundation, and the National Institutes of Health. Hue H. Luu was a recipient of the OREF Resident Research Award.

Keywords

Anchorage independent growth
Cell motility
EF-hand proteins
Metastasis
Osteosarcoma
S100A6

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.canlet.2005.02.015

Cite this

Luu, H. H., Zhou, L., Haydon, R. C., Deyrup, A. T., Montag, A. G., Huo, D., Heck, R., Heizmann, C. W., Peabody, T. D., Simon, M. A., & He, T. C. (2005). Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma. Cancer Letters, 229(1), 135-148. https://doi.org/10.1016/j.canlet.2005.02.015

@article{3e86ceefd2c74484a71f0884219c75d5,

title = "Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma",

abstract = "While most osteosarcoma patients have metastatic or micrometastatic lesions, less than 15% of them have clinically detectable metastatic diseases at presentation. To identify potential markers that may predict osteosarcoma metastasis, we analyzed the expression of S100A6 in 50 osteosarcoma cases and found that 84% of the analyzed specimens stained positive for S100A6. There is a trend towards decreased clinically evident metastasis with increased S100A6 staining. Overexpression of S100A6 in osteosarcoma cells decreases cell motility and anchorage independent growth on collagen gels. Our findings provide evidence that, while S100A6 is commonly overexpressed in human osteosarcoma, loss of its expression correlates with a metastatic phenotype.",

keywords = "Anchorage independent growth, Cell motility, EF-hand proteins, Metastasis, Osteosarcoma, S100A6",

author = "Luu, {Hue H.} and Lan Zhou and Haydon, {Rex C.} and Deyrup, {Andrea T.} and Montag, {Anthony G.} and Dezheng Huo and Robert Heck and Heizmann, {Claus W.} and Peabody, {Terrance D.} and Simon, {Michael A.} and He, {Tong Chuan}",

note = "Funding Information: We would like to thank the staff at The University of Chicago Cancer Registry for their valuable assistance. This work was supported in part by research grants from The Brinson Foundation, the Orthopedic Research and Education Foundation, and the National Institutes of Health. Hue H. Luu was a recipient of the OREF Resident Research Award.",

year = "2005",

month = nov,

day = "8",

doi = "10.1016/j.canlet.2005.02.015",

language = "English (US)",

volume = "229",

pages = "135--148",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

Luu, HH, Zhou, L, Haydon, RC, Deyrup, AT, Montag, AG, Huo, D, Heck, R, Heizmann, CW, Peabody, TD, Simon, MA & He, TC 2005, 'Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma', Cancer Letters, vol. 229, no. 1, pp. 135-148. https://doi.org/10.1016/j.canlet.2005.02.015

TY - JOUR

T1 - Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma

AU - Luu, Hue H.

AU - Zhou, Lan

AU - Haydon, Rex C.

AU - Deyrup, Andrea T.

AU - Montag, Anthony G.

AU - Huo, Dezheng

AU - Heck, Robert

AU - Heizmann, Claus W.

AU - Peabody, Terrance D.

AU - Simon, Michael A.

AU - He, Tong Chuan

N1 - Funding Information: We would like to thank the staff at The University of Chicago Cancer Registry for their valuable assistance. This work was supported in part by research grants from The Brinson Foundation, the Orthopedic Research and Education Foundation, and the National Institutes of Health. Hue H. Luu was a recipient of the OREF Resident Research Award.

PY - 2005/11/8

Y1 - 2005/11/8

N2 - While most osteosarcoma patients have metastatic or micrometastatic lesions, less than 15% of them have clinically detectable metastatic diseases at presentation. To identify potential markers that may predict osteosarcoma metastasis, we analyzed the expression of S100A6 in 50 osteosarcoma cases and found that 84% of the analyzed specimens stained positive for S100A6. There is a trend towards decreased clinically evident metastasis with increased S100A6 staining. Overexpression of S100A6 in osteosarcoma cells decreases cell motility and anchorage independent growth on collagen gels. Our findings provide evidence that, while S100A6 is commonly overexpressed in human osteosarcoma, loss of its expression correlates with a metastatic phenotype.

AB - While most osteosarcoma patients have metastatic or micrometastatic lesions, less than 15% of them have clinically detectable metastatic diseases at presentation. To identify potential markers that may predict osteosarcoma metastasis, we analyzed the expression of S100A6 in 50 osteosarcoma cases and found that 84% of the analyzed specimens stained positive for S100A6. There is a trend towards decreased clinically evident metastasis with increased S100A6 staining. Overexpression of S100A6 in osteosarcoma cells decreases cell motility and anchorage independent growth on collagen gels. Our findings provide evidence that, while S100A6 is commonly overexpressed in human osteosarcoma, loss of its expression correlates with a metastatic phenotype.

KW - Anchorage independent growth

KW - Cell motility

KW - EF-hand proteins

KW - Metastasis

KW - Osteosarcoma

KW - S100A6

UR - http://www.scopus.com/inward/record.url?scp=24344469433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24344469433&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2005.02.015

DO - 10.1016/j.canlet.2005.02.015

M3 - Article

C2 - 16157226

AN - SCOPUS:24344469433

SN - 0304-3835

VL - 229

SP - 135

EP - 148

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this