Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma

Hue H. Luu, Lan Zhou, Rex C. Haydon, Andrea T. Deyrup, Anthony G. Montag, Dezheng Huo, Robert Heck, Claus W. Heizmann, Terrance D. Peabody, Michael A. Simon, Tong Chuan He*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

While most osteosarcoma patients have metastatic or micrometastatic lesions, less than 15% of them have clinically detectable metastatic diseases at presentation. To identify potential markers that may predict osteosarcoma metastasis, we analyzed the expression of S100A6 in 50 osteosarcoma cases and found that 84% of the analyzed specimens stained positive for S100A6. There is a trend towards decreased clinically evident metastasis with increased S100A6 staining. Overexpression of S100A6 in osteosarcoma cells decreases cell motility and anchorage independent growth on collagen gels. Our findings provide evidence that, while S100A6 is commonly overexpressed in human osteosarcoma, loss of its expression correlates with a metastatic phenotype.

Original languageEnglish (US)
Pages (from-to)135-148
Number of pages14
JournalCancer Letters
Volume229
Issue number1
DOIs
StatePublished - Nov 8 2005

Keywords

  • Anchorage independent growth
  • Cell motility
  • EF-hand proteins
  • Metastasis
  • Osteosarcoma
  • S100A6

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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