Increased fibrinolytic activity in patients undergoing cardiopulmonary bypass operation

Omer Kucuk*, Hau C. Kwaan, James Frederickson, Leonard Wade, David Green

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


The influence of cardiopulmonary bypass on fibrinolytic activity was assessed by a sensitive clot lysis assay in eight patients undergoing coronary artery bypass operations. Fibrinolytic activity increased immediately after cardíopulmonary bypass was begun and remained elevated throughout the period of extracorporeal circulation. At the conclusion of the operative procedure, fibrinolytic activity returned to the normal range in all patients, and no subject had postoperative bleeding.

Original languageEnglish (US)
Pages (from-to)223-229
Number of pages7
JournalAmerican Journal of Hematology
Issue number3
StatePublished - Nov 1986


  • clot lysis assay
  • hemodilution
  • hypothermia

ASJC Scopus subject areas

  • Hematology


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