Increased microvascular density predicts relapse in Wilms' tumor

Lisa P. Abramson, Paul E. Grundy, Alfred W. Rademaker, Irene Helenowski, Mona Cornwell, Howard M. Katzenstein, Marleta Reynolds, Robert M. Arensman, Susan E. Crawford*, G. Gittes, J. Grosfeld, T. Tracy

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Background/Purpose: Tumor stage and histology are the most important prognostic criteria in Wilms' tumors; however, a subset of patients remains who have favorable histology tumors and unexpectedly relapse. The authors postulated that increased microvascular density (MVD), a hallmark for angiogenesis, could identify patients at risk for relapse. Methods: A case-control study was used to compare relapse (n = 15) with nonrelapse tumors (n = 35). Tumor MVD was counted in 5 random high-powered fields (hpf) using anti-Factor VIII antibody and expressed as mean vessel count/hpf +/- SEM. MVD and clinical data were evaluated using univariate analysis and student's t test. Results: The relapse group had higher MVD than the nonrelapse group (34.9 +/- 2.9 v 22.4 +/- 2; P < .05). When evaluating the favorable histology (FH) group alone, there was higher MVD in the relapse group (32.4 +/- 2.7 v 19 +/-1.8; P < .05). MVD was found to be the only predictor of relapse when compared with age, sex, tumor weight, and histology. Conclusions: These results suggest that increased MVD can identify Wilms' tumor patients at high risk for relapse, especially those patients with favorable histology tumors. A larger study is warranted to determine the potential utility of MVD in stratification of Wilms' tumor patients.

Original languageEnglish (US)
Pages (from-to)325-330
Number of pages6
JournalJournal of Pediatric Surgery
Volume38
Issue number3
DOIs
StatePublished - Mar 1 2003

Keywords

  • Angiogenesis
  • Favorable histology
  • Microvascular density
  • Relapse
  • Wilms'tumor

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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    Abramson, L. P., Grundy, P. E., Rademaker, A. W., Helenowski, I., Cornwell, M., Katzenstein, H. M., Reynolds, M., Arensman, R. M., Crawford, S. E., Gittes, G., Grosfeld, J., & Tracy, T. (2003). Increased microvascular density predicts relapse in Wilms' tumor. Journal of Pediatric Surgery, 38(3), 325-330. https://doi.org/10.1053/jpsu.2003.50102