Increased myocardial infarct size because of reduced coronary collateral blood flow in beagles

N. Uemura, D. R. Knight, Y. T. Shen, J. Nejima, M. V. Cohen, J. X. Thomas, S. F. Vatner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Effects of permanent left circumflex coronary artery occlusion (CAO) were examined in conscious purebred beagles and mongrel dogs, instrumented with miniature left ventricular (LV) pressure gauges, wall thickness gauges in the ischemic zone, catheters in left atrium, and aorta, and snares around the left circumflex coronary artery. Blood flow was measured using the radioactive microsphere technique before CAO and at 5 min, 1, 3, and 24 h after CAO. Although CAO reduced myocardial blood flow similarly in beagles and mongrels, significantly less (P < 0.05) recovery of myocardial blood flow was observed over the following 24-h period in beagles. Infarct size, as determined by triphenyltetrazolium chloride and expressed as percentage of area at risk, was larger (P < 0.05) in beagles (62.0 ± 5.1%) than mongrels (42.5 ± 4.2%). Thus beagles do not tolerate ischemia as well as mongrel dogs and possess fewer functional coronary collaterals resulting in larger infarcts after CAO.

Original languageEnglish (US)
Pages (from-to)26/6
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume257
Issue number6
StatePublished - 1989

Keywords

  • coronary artery occlusion
  • coronary blood flow
  • myocardial ischemia
  • species difference
  • wall thickness

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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