Increased osteoblast proliferation on hydroxyapatite thin coatings produced by right angle magnetron sputtering

Zhendong Hong*, Alexandre Mello, Tomohiko Yoshida, Lan Luan, Paula H. Stern, Alexandre Rossi, Donald E. Ellis, John B. Ketterson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Crystalline hydroxyapatite thin coatings have been prepared using a novel opposing RF magnetron sputtering approach at room temperature. X-ray diffraction (XRD) analysis shows that all the principal peaks are attributable to HA, and the as-deposited HA coatings are made up of crystallites in the size range of 50-100nm. Fourier transform infrared spectroscopy (FTIR) studies reveal the existence of phosphate, carbonate and hydroxyl groups, suggesting that HA coatings are highly crystalline. To study the biocompatibility of these coatings, murine osteoblast cells were seeded onto various substrates. Cell density counts using fluorescence microscopy show that the best osteoblast proliferation is achieved on an HA RAMS-coated titanium substrate. These experiments demonstrate that RAMS is a promising coating technique for biomedical applications.

Original languageEnglish (US)
Pages (from-to)215-218
Number of pages4
JournalKey Engineering Materials
Volume361-363 I
StatePublished - Jan 1 2008

Keywords

  • Cell culture
  • Crystallinity
  • Heat treatment
  • Hydroxyapatite
  • Magnetron sputtering
  • Thin coatings

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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