TY - JOUR
T1 - Increased percentage of HLA-DR T cells in untreated juvenile dermatomyositis
AU - Khojah, Amer Mohammad
AU - Schutt, Madeline
AU - Morgan, Gabrielle
AU - Bukhari, Ameera
AU - Bensen, Nicolas
AU - Khanolkar, Aaruni
AU - Pachman, Lauren M.
N1 - Publisher Copyright:
© 2024
PY - 2024/6
Y1 - 2024/6
N2 - This study investigates HLA-DR expression on activated T cells and serum neopterin levels in Juvenile Dermatomyositis (JDM) children pre- and post-treatment. Sixty-nine JDM children (less than 18 years) were included. Elevated HLA-DR+ T cells (>7 %) were observed in 19 % of untreated cases. Post-treatment, mean HLA-DR+ T cells decreased from 5.1 to 2.9 (P < 0.001), and serum neopterin levels declined from 19.3 to 9.1 nmol/L (P < 0.0001). A positive correlation between serum neopterin and HLA-DR T cell percentage was observed (r = 0.39, P = 0.01). Intravenous steroid treatment exhibited a 47.4 % improvement in HLA-DR+ T cells and a 50.5 % reduction in serum neopterin levels, in contrast to 14.8 % and 34.1 % in the oral steroid group. In conclusion, treatment, particularly with IV steroids, significantly improved HLA-DR+ T cells percentage and neopterin levels. A correlation between HLA-DR+ T cells percentage and serum neopterin was noted in untreated JDM patients.
AB - This study investigates HLA-DR expression on activated T cells and serum neopterin levels in Juvenile Dermatomyositis (JDM) children pre- and post-treatment. Sixty-nine JDM children (less than 18 years) were included. Elevated HLA-DR+ T cells (>7 %) were observed in 19 % of untreated cases. Post-treatment, mean HLA-DR+ T cells decreased from 5.1 to 2.9 (P < 0.001), and serum neopterin levels declined from 19.3 to 9.1 nmol/L (P < 0.0001). A positive correlation between serum neopterin and HLA-DR T cell percentage was observed (r = 0.39, P = 0.01). Intravenous steroid treatment exhibited a 47.4 % improvement in HLA-DR+ T cells and a 50.5 % reduction in serum neopterin levels, in contrast to 14.8 % and 34.1 % in the oral steroid group. In conclusion, treatment, particularly with IV steroids, significantly improved HLA-DR+ T cells percentage and neopterin levels. A correlation between HLA-DR+ T cells percentage and serum neopterin was noted in untreated JDM patients.
KW - HLA-DR+T cell
KW - Juvenile dermatomyositis
KW - Neopterin
UR - http://www.scopus.com/inward/record.url?scp=85195054991&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85195054991&partnerID=8YFLogxK
U2 - 10.1016/j.clicom.2024.02.002
DO - 10.1016/j.clicom.2024.02.002
M3 - Article
C2 - 38962376
AN - SCOPUS:85195054991
SN - 2772-6134
VL - 5
SP - 20
EP - 25
JO - Clinical Immunology Communications
JF - Clinical Immunology Communications
ER -