Increased postural sway predicts negative symptom progression in youth at ultrahigh risk for psychosis

Derek J. Dean*, Jerillyn S. Kent, Jessica A. Bernard, Joseph M. Orr, Tina Gupta, Andrea Pelletier-Baldelli, Emily E. Carol, Vijay A. Mittal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Impaired ability to maintain an upright posture may reflect impairment in the cerebellum, a critical structure for the fluid coordination of neural information, thought to be disrupted in psychosis. The current study utilized an instrumental measure of posture in individuals at ultrahigh risk (UHR) for psychosis (n= 43) and healthy controls (n= 44). Positive and negative symptoms were assessed twice over 12. months. Results showed that increased postural sway in the UHR group predicted changes in negative symptoms. This study provides an important prospective view on the relationship between cerebellar-sensitive behavior and integral symptoms, which until now has received limited biomarker research.

Original languageEnglish (US)
Pages (from-to)86-89
Number of pages4
JournalSchizophrenia Research
Volume162
Issue number1-3
DOIs
StatePublished - Jan 1 2015

Keywords

  • Cerebellum
  • Cognitive dysmetria
  • Postural sway
  • Psychosis
  • Ultrahigh risk

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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