Increased postural sway predicts negative symptom progression in youth at ultrahigh risk for psychosis

Derek J. Dean; Jerillyn S. Kent; Jessica A. Bernard; Joseph M. Orr; Tina Gupta; Andrea Pelletier-Baldelli; Emily E. Carol; Vijay A. Mittal

doi:10.1016/j.schres.2014.12.039

Increased postural sway predicts negative symptom progression in youth at ultrahigh risk for psychosis

Derek J. Dean^*, Jerillyn S. Kent, Jessica A. Bernard, Joseph M. Orr, Tina Gupta, Andrea Pelletier-Baldelli, Emily E. Carol, Vijay A. Mittal

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Impaired ability to maintain an upright posture may reflect impairment in the cerebellum, a critical structure for the fluid coordination of neural information, thought to be disrupted in psychosis. The current study utilized an instrumental measure of posture in individuals at ultrahigh risk (UHR) for psychosis (n= 43) and healthy controls (n= 44). Positive and negative symptoms were assessed twice over 12. months. Results showed that increased postural sway in the UHR group predicted changes in negative symptoms. This study provides an important prospective view on the relationship between cerebellar-sensitive behavior and integral symptoms, which until now has received limited biomarker research.

Original language	English (US)
Pages (from-to)	86-89
Number of pages	4
Journal	Schizophrenia Research
Volume	162
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2014.12.039
State	Published - Mar 1 2015

Keywords

Cerebellum
Cognitive dysmetria
Postural sway
Psychosis
Ultrahigh risk

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.schres.2014.12.039

Cite this

@article{b1f046b320e64e3ca3bde74151156c09,

title = "Increased postural sway predicts negative symptom progression in youth at ultrahigh risk for psychosis",

abstract = "Impaired ability to maintain an upright posture may reflect impairment in the cerebellum, a critical structure for the fluid coordination of neural information, thought to be disrupted in psychosis. The current study utilized an instrumental measure of posture in individuals at ultrahigh risk (UHR) for psychosis (n= 43) and healthy controls (n= 44). Positive and negative symptoms were assessed twice over 12. months. Results showed that increased postural sway in the UHR group predicted changes in negative symptoms. This study provides an important prospective view on the relationship between cerebellar-sensitive behavior and integral symptoms, which until now has received limited biomarker research.",

keywords = "Cerebellum, Cognitive dysmetria, Postural sway, Psychosis, Ultrahigh risk",

author = "Dean, {Derek J.} and Kent, {Jerillyn S.} and Bernard, {Jessica A.} and Orr, {Joseph M.} and Tina Gupta and Andrea Pelletier-Baldelli and Carol, {Emily E.} and Mittal, {Vijay A.}",

note = "Funding Information: This work was supported by National Institutes of Health grant nos. R01MH094650 and R21/R33MH103231 to V.A.M. J.A.B. is currently supported by F32MH102989-01 . J.M.O. is supported by F32DA034412-01A1 . A.P.B is supported by F31MH100821-01A1 . Publisher Copyright: {\textcopyright} 2015.",

year = "2015",

month = mar,

day = "1",

doi = "10.1016/j.schres.2014.12.039",

language = "English (US)",

volume = "162",

pages = "86--89",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier",

number = "1-3",

}

TY - JOUR

T1 - Increased postural sway predicts negative symptom progression in youth at ultrahigh risk for psychosis

AU - Dean, Derek J.

AU - Kent, Jerillyn S.

AU - Bernard, Jessica A.

AU - Orr, Joseph M.

AU - Gupta, Tina

AU - Pelletier-Baldelli, Andrea

AU - Carol, Emily E.

AU - Mittal, Vijay A.

N1 - Funding Information: This work was supported by National Institutes of Health grant nos. R01MH094650 and R21/R33MH103231 to V.A.M. J.A.B. is currently supported by F32MH102989-01 . J.M.O. is supported by F32DA034412-01A1 . A.P.B is supported by F31MH100821-01A1 . Publisher Copyright: © 2015.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Impaired ability to maintain an upright posture may reflect impairment in the cerebellum, a critical structure for the fluid coordination of neural information, thought to be disrupted in psychosis. The current study utilized an instrumental measure of posture in individuals at ultrahigh risk (UHR) for psychosis (n= 43) and healthy controls (n= 44). Positive and negative symptoms were assessed twice over 12. months. Results showed that increased postural sway in the UHR group predicted changes in negative symptoms. This study provides an important prospective view on the relationship between cerebellar-sensitive behavior and integral symptoms, which until now has received limited biomarker research.

AB - Impaired ability to maintain an upright posture may reflect impairment in the cerebellum, a critical structure for the fluid coordination of neural information, thought to be disrupted in psychosis. The current study utilized an instrumental measure of posture in individuals at ultrahigh risk (UHR) for psychosis (n= 43) and healthy controls (n= 44). Positive and negative symptoms were assessed twice over 12. months. Results showed that increased postural sway in the UHR group predicted changes in negative symptoms. This study provides an important prospective view on the relationship between cerebellar-sensitive behavior and integral symptoms, which until now has received limited biomarker research.

KW - Cerebellum

KW - Cognitive dysmetria

KW - Postural sway

KW - Psychosis

KW - Ultrahigh risk

UR - http://www.scopus.com/inward/record.url?scp=84923226539&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923226539&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2014.12.039

DO - 10.1016/j.schres.2014.12.039

M3 - Article

C2 - 25601361

AN - SCOPUS:84923226539

SN - 0920-9964

VL - 162

SP - 86

EP - 89

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -

Increased postural sway predicts negative symptom progression in youth at ultrahigh risk for psychosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this