Abstract
The cellullar immune response is important in the containment of progressive multifocal leukoencephalopathy (PML). We examined program cell death-1 (PD-1) expression, a marker of cellular immune exhaustion, on T lymphocytes in PML. PD-1 expression was elevated on total CD4 and CD8 T cells (medians 36% and 24%) in PML patients compared with healthy control subjects (medians 14% and 18%; P = 0.0015 and P = 0.033). In PML patients, JC virus (JCV)-specific CD8 cytotoxic T lymphocytes expressed PD-1 more frequently than total CD8 T lymphocytes (means 39% and 78%, P = 0.0004). Blocking the PD-1 receptor increased JCV-specific T-cell immune response in a subgroup of PML patients.
Original language | English (US) |
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Pages (from-to) | 244-248 |
Number of pages | 5 |
Journal | Journal of Acquired Immune Deficiency Syndromes |
Volume | 60 |
Issue number | 3 |
DOIs | |
State | Published - Jul 1 2012 |
Keywords
- PD-1
- PML
- immune exhaustion
- immunotherapy
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)