Increased program cell death-1 expression on T lymphocytes of patients with progressive multifocal leukoencephalopathy

Chen Sabrina Tan; Evelyn Bord; Thomas A. Broge; Brett Glotzbecker; Heidi Mills; Sarah Gheuens; Jacalyn Rosenblatt; David Avigan; Igor J. Koralnik

doi:10.1097/QAI.0b013e31825a313c

Increased program cell death-1 expression on T lymphocytes of patients with progressive multifocal leukoencephalopathy

Chen Sabrina Tan^*, Evelyn Bord, Thomas A. Broge, Brett Glotzbecker, Heidi Mills, Sarah Gheuens, Jacalyn Rosenblatt, David Avigan, Igor J. Koralnik

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The cellullar immune response is important in the containment of progressive multifocal leukoencephalopathy (PML). We examined program cell death-1 (PD-1) expression, a marker of cellular immune exhaustion, on T lymphocytes in PML. PD-1 expression was elevated on total CD4 and CD8 T cells (medians 36% and 24%) in PML patients compared with healthy control subjects (medians 14% and 18%; P = 0.0015 and P = 0.033). In PML patients, JC virus (JCV)-specific CD8 cytotoxic T lymphocytes expressed PD-1 more frequently than total CD8 T lymphocytes (means 39% and 78%, P = 0.0004). Blocking the PD-1 receptor increased JCV-specific T-cell immune response in a subgroup of PML patients.

Original language	English (US)
Pages (from-to)	244-248
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	60
Issue number	3
DOIs	https://doi.org/10.1097/QAI.0b013e31825a313c
State	Published - Jul 1 2012

Keywords

PD-1
PML
immune exhaustion
immunotherapy

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/QAI.0b013e31825a313c

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title = "Increased program cell death-1 expression on T lymphocytes of patients with progressive multifocal leukoencephalopathy",

abstract = "The cellullar immune response is important in the containment of progressive multifocal leukoencephalopathy (PML). We examined program cell death-1 (PD-1) expression, a marker of cellular immune exhaustion, on T lymphocytes in PML. PD-1 expression was elevated on total CD4 and CD8 T cells (medians 36% and 24%) in PML patients compared with healthy control subjects (medians 14% and 18%; P = 0.0015 and P = 0.033). In PML patients, JC virus (JCV)-specific CD8 cytotoxic T lymphocytes expressed PD-1 more frequently than total CD8 T lymphocytes (means 39% and 78%, P = 0.0004). Blocking the PD-1 receptor increased JCV-specific T-cell immune response in a subgroup of PML patients.",

keywords = "PD-1, PML, immune exhaustion, immunotherapy",

author = "Tan, {Chen Sabrina} and Evelyn Bord and Broge, {Thomas A.} and Brett Glotzbecker and Heidi Mills and Sarah Gheuens and Jacalyn Rosenblatt and David Avigan and Koralnik, {Igor J.}",

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doi = "10.1097/QAI.0b013e31825a313c",

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AU - Tan, Chen Sabrina

AU - Bord, Evelyn

AU - Broge, Thomas A.

AU - Glotzbecker, Brett

AU - Mills, Heidi

AU - Gheuens, Sarah

AU - Rosenblatt, Jacalyn

AU - Avigan, David

AU - Koralnik, Igor J.

PY - 2012/7/1

Y1 - 2012/7/1

N2 - The cellullar immune response is important in the containment of progressive multifocal leukoencephalopathy (PML). We examined program cell death-1 (PD-1) expression, a marker of cellular immune exhaustion, on T lymphocytes in PML. PD-1 expression was elevated on total CD4 and CD8 T cells (medians 36% and 24%) in PML patients compared with healthy control subjects (medians 14% and 18%; P = 0.0015 and P = 0.033). In PML patients, JC virus (JCV)-specific CD8 cytotoxic T lymphocytes expressed PD-1 more frequently than total CD8 T lymphocytes (means 39% and 78%, P = 0.0004). Blocking the PD-1 receptor increased JCV-specific T-cell immune response in a subgroup of PML patients.

AB - The cellullar immune response is important in the containment of progressive multifocal leukoencephalopathy (PML). We examined program cell death-1 (PD-1) expression, a marker of cellular immune exhaustion, on T lymphocytes in PML. PD-1 expression was elevated on total CD4 and CD8 T cells (medians 36% and 24%) in PML patients compared with healthy control subjects (medians 14% and 18%; P = 0.0015 and P = 0.033). In PML patients, JC virus (JCV)-specific CD8 cytotoxic T lymphocytes expressed PD-1 more frequently than total CD8 T lymphocytes (means 39% and 78%, P = 0.0004). Blocking the PD-1 receptor increased JCV-specific T-cell immune response in a subgroup of PML patients.

KW - PD-1

KW - PML

KW - immune exhaustion

KW - immunotherapy

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Increased program cell death-1 expression on T lymphocytes of patients with progressive multifocal leukoencephalopathy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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