Increased program cell death-1 expression on T lymphocytes of patients with progressive multifocal leukoencephalopathy

Chen Sabrina Tan*, Evelyn Bord, Thomas A. Broge, Brett Glotzbecker, Heidi Mills, Sarah Gheuens, Jacalyn Rosenblatt, David Avigan, Igor J. Koralnik

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The cellullar immune response is important in the containment of progressive multifocal leukoencephalopathy (PML). We examined program cell death-1 (PD-1) expression, a marker of cellular immune exhaustion, on T lymphocytes in PML. PD-1 expression was elevated on total CD4 and CD8 T cells (medians 36% and 24%) in PML patients compared with healthy control subjects (medians 14% and 18%; P = 0.0015 and P = 0.033). In PML patients, JC virus (JCV)-specific CD8 cytotoxic T lymphocytes expressed PD-1 more frequently than total CD8 T lymphocytes (means 39% and 78%, P = 0.0004). Blocking the PD-1 receptor increased JCV-specific T-cell immune response in a subgroup of PML patients.

Original languageEnglish (US)
Pages (from-to)244-248
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume60
Issue number3
DOIs
StatePublished - Jul 1 2012

Keywords

  • PD-1
  • PML
  • immune exhaustion
  • immunotherapy

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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