Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats

M. S. Rao; V. Subbarao; J. K. Reddy

doi:10.1016/0304-3835(86)90036-4

Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats

M. S. Rao^*, V. Subbarao, J. K. Reddy

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Altered areas (AA), neoplastic nodules (NN) and hepatocellular carcinomas (HCC) induced by chronic administration of ciprofibrate and Wy-14,643 were examined for iron accumulation after systemic iron overload. Eighty percent of AA, 90% NN and 100% HCC showed increased resistance to iron accumulation. However, marked heterogeneity was observed in the amount of iron from area to area within the same lesion with some cells containing no iron, while others showing blue reaction to iron. These findings indicate, that putative preneoplastic and neoplastic hepatic lesions induced by peroxi-some proliferators exclude iron in a fashion similar to that of hepatic nodules and carcinomas induced by DNA damaging carcinogens.

Original language	English (US)
Pages (from-to)	33-39
Number of pages	7
Journal	Cancer Letters
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(86)90036-4
State	Published - Jul 1986

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats",

abstract = "Altered areas (AA), neoplastic nodules (NN) and hepatocellular carcinomas (HCC) induced by chronic administration of ciprofibrate and Wy-14,643 were examined for iron accumulation after systemic iron overload. Eighty percent of AA, 90% NN and 100% HCC showed increased resistance to iron accumulation. However, marked heterogeneity was observed in the amount of iron from area to area within the same lesion with some cells containing no iron, while others showing blue reaction to iron. These findings indicate, that putative preneoplastic and neoplastic hepatic lesions induced by peroxi-some proliferators exclude iron in a fashion similar to that of hepatic nodules and carcinomas induced by DNA damaging carcinogens.",

author = "Rao, {M. S.} and V. Subbarao and Reddy, {J. K.}",

note = "Funding Information: This work is supported by NIH researchg rants CA 36130 and GM 23750. We thank Karen McGhee for secretarial assistance.",

year = "1986",

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doi = "10.1016/0304-3835(86)90036-4",

language = "English (US)",

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T1 - Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats

AU - Rao, M. S.

AU - Subbarao, V.

AU - Reddy, J. K.

N1 - Funding Information: This work is supported by NIH researchg rants CA 36130 and GM 23750. We thank Karen McGhee for secretarial assistance.

PY - 1986/7

Y1 - 1986/7

N2 - Altered areas (AA), neoplastic nodules (NN) and hepatocellular carcinomas (HCC) induced by chronic administration of ciprofibrate and Wy-14,643 were examined for iron accumulation after systemic iron overload. Eighty percent of AA, 90% NN and 100% HCC showed increased resistance to iron accumulation. However, marked heterogeneity was observed in the amount of iron from area to area within the same lesion with some cells containing no iron, while others showing blue reaction to iron. These findings indicate, that putative preneoplastic and neoplastic hepatic lesions induced by peroxi-some proliferators exclude iron in a fashion similar to that of hepatic nodules and carcinomas induced by DNA damaging carcinogens.

AB - Altered areas (AA), neoplastic nodules (NN) and hepatocellular carcinomas (HCC) induced by chronic administration of ciprofibrate and Wy-14,643 were examined for iron accumulation after systemic iron overload. Eighty percent of AA, 90% NN and 100% HCC showed increased resistance to iron accumulation. However, marked heterogeneity was observed in the amount of iron from area to area within the same lesion with some cells containing no iron, while others showing blue reaction to iron. These findings indicate, that putative preneoplastic and neoplastic hepatic lesions induced by peroxi-some proliferators exclude iron in a fashion similar to that of hepatic nodules and carcinomas induced by DNA damaging carcinogens.

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