Increased resting energy expenditure is associated with failure to thrive in infants with severe combined immunodeficiency

Mary A. Barron, Melanie Makhija, Lorrie E M Hagen, Paul Pencharz, Eyal Grunebaum, Chaim M. Roifman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Objectives: To measure resting energy expenditure (REE) and determine whether increased REE (hypermetabolism) is associated with failure to thrive (FTT) in patients with severe combined immunodeficiency (SCID) at diagnosis. Study design: REE was measured in 26 patients with SCID in a single transplant center. Predicted REE was determined with World Health Organization standards. Measured REE >110% of predicted REE was classified as hypermetabolism. Other data collected included FTT status, infections, genotype, phenotype, and the feeding methods used. Results: Fifteen of 26 patients (57.7%) had FTT, and 18 of 26 patients (69.2%) were hypermetabolic. Hypermetabolism occured in 14 of 15 patients (93%) with FTT, and only 4 of 11 patients (36%) without FTT had hypermetabolism (P =.003). There was a significant difference between the measured REE (71.75 ± 16.6 kcal/kg) and the predicted REE (52.85 ± 2.8 kcal/kg; P <.0001). Eleven of 17 patients (65%) required nasogastric feeding, parenteral nutrition, or both to meet their energy needs. Conclusions: Hypermetabolism is common in patients with SCID and may contribute to the development of FTT. The hypermetabolism in these patients may necessitate intensive nutrition support.

Original languageEnglish (US)
Pages (from-to)628-632.e1
JournalJournal of Pediatrics
Issue number4
StatePublished - Oct 2011


  • BMT
  • Bone marrow transplant
  • FTT
  • Failure to thrive
  • IC
  • Indirect calorimetry
  • LAF
  • Laminar air flow
  • NG
  • Nasogastric
  • PN
  • Parenteral nutrition
  • REE
  • Resting energy expenditure
  • SCID
  • Severe combined immunodeficiency
  • SickKids
  • The Hospital for Sick Children

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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