TY - JOUR
T1 - Increased serum concentrations of 1,25(OH)2 vitamin D in children with fasting hypercalciuria
AU - Stapleton, F. Bruder
AU - Langman, Craig B.
AU - Bittle, Joyce
AU - Miller, Leslie A.
N1 - Funding Information:
Idiopathic hypercalciuria is an important cause of urolithiasis in children and adults ~-4 and of isolated hematuria in children. 5 Increased urinary excretion of calcium may occur from either increased gastrointestinal absorption of Supported in part by grants from the Public Health Service (RR 00211-19) and the National Institutes of Health (AM36821) . Dr. Stapleton is the recipient of a Clinical Associate Physician Award, and Dr. Langman is the recipient of a New Investigator Award. Presented in part at the Southern Society for Pediatric Research and Southern Section, American Federation for Clinical Research, February 1986, New Orleans, and at the Annual Meeting of the Society for Pediatric Research, May 1986, Washington, D.C. Submitted for publication June 16, 1986; accepted Sept. 8, 1986. Reprint requests: F. Bruder Stapleton, M.D., Pediatric Research Laboratory, 956 Court Ave., Room B310, Memphis, TN 38163.
PY - 1987/2
Y1 - 1987/2
N2 - Inappropriately elevated concentrations of 1,25(OH)2 vitamin D in serum appear to be responsible for excessive gastrointestinal absorption of dietary calcium in patients with absorptive hypercalcluria. We have examined serum 1,25(OH)2 vitamin D concentrations in another group of children with hypercalciuria in whom urinary calcium excretion was excessive after an overnight fast. Eleven children with idiopathic fasting hypercalciuria (IH) (urinary calcium excretion >4 mg/kg/24 hr and fasting urinary calcium/urinary creatinine ratio >0.21) and seven healthy children were observed while they were eating a diet containing 1 gm calcium per day. Fasting serum 1,25(OH)2 vitamin D concentrations were elevated in children with IH compared with control values (35.3±3.2 vs 21±2 pg/ml, P=0.003), whereas fasting serum parathyroid hormone, 25-OH vitamin D, phosphorus, and ionized calcium concentrations were similar in the two groups. These data suggest that disordered 1,25(OH)2 vitamin D metabolism occurs in children with fasting IH. Absorptive and fasting IH may represent a spectrum of a single disorder characterized by excessive urinary calcium excretion and inappropriately elevated serum concentrations of 1,25(OH)2 vitamin D.
AB - Inappropriately elevated concentrations of 1,25(OH)2 vitamin D in serum appear to be responsible for excessive gastrointestinal absorption of dietary calcium in patients with absorptive hypercalcluria. We have examined serum 1,25(OH)2 vitamin D concentrations in another group of children with hypercalciuria in whom urinary calcium excretion was excessive after an overnight fast. Eleven children with idiopathic fasting hypercalciuria (IH) (urinary calcium excretion >4 mg/kg/24 hr and fasting urinary calcium/urinary creatinine ratio >0.21) and seven healthy children were observed while they were eating a diet containing 1 gm calcium per day. Fasting serum 1,25(OH)2 vitamin D concentrations were elevated in children with IH compared with control values (35.3±3.2 vs 21±2 pg/ml, P=0.003), whereas fasting serum parathyroid hormone, 25-OH vitamin D, phosphorus, and ionized calcium concentrations were similar in the two groups. These data suggest that disordered 1,25(OH)2 vitamin D metabolism occurs in children with fasting IH. Absorptive and fasting IH may represent a spectrum of a single disorder characterized by excessive urinary calcium excretion and inappropriately elevated serum concentrations of 1,25(OH)2 vitamin D.
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U2 - 10.1016/S0022-3476(87)80160-9
DO - 10.1016/S0022-3476(87)80160-9
M3 - Article
C2 - 3806294
AN - SCOPUS:0023100361
SN - 0022-3476
VL - 110
SP - 234
EP - 237
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 2
ER -