Abstract
(1) Serum prolactin levels of six women, who developed psychoses during the postpartum period and were treated with neuroleptic drugs, were higher than those of a group of non-postpartum women of comparable age treated with similar doses of these drugs. (2) The magnitude of the neuroleptic-induced elevations in serum prolactin diminished with time during the postpartum period and returned to that found in non-parturient drug-treated females approximately 120 days postpartum. (3) A similar increased responsiveness of the hypothalamic-pituitary axis controlling prolactin secretion in postpartum females is manifested by the suckling response and increased prolactin response to thyrotrophin releasing hormone (TRH). The time course of normalization of these enhanced endocrine responses is roughly similar to that found for normalization of the prolactin response to neuroleptic drugs. A common mechanism may underlie each of these phenomena.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 345-351 |
| Number of pages | 7 |
| Journal | Psychoneuroendocrinology |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1980 |
Fingerprint
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Endocrine and Autonomic Systems
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
}
Increased serum prolactin levels during phenothiazine and butyrophenone treatment of six postpartum women. / Goode, David J.; Meltzer, Herbert Y.; Fang, Victor S.
In: Psychoneuroendocrinology, Vol. 5, No. 4, 01.01.1980, p. 345-351.Research output: Contribution to journal › Article
TY - JOUR
T1 - Increased serum prolactin levels during phenothiazine and butyrophenone treatment of six postpartum women
AU - Goode, David J.
AU - Meltzer, Herbert Y.
AU - Fang, Victor S.
PY - 1980/1/1
Y1 - 1980/1/1
N2 - (1) Serum prolactin levels of six women, who developed psychoses during the postpartum period and were treated with neuroleptic drugs, were higher than those of a group of non-postpartum women of comparable age treated with similar doses of these drugs. (2) The magnitude of the neuroleptic-induced elevations in serum prolactin diminished with time during the postpartum period and returned to that found in non-parturient drug-treated females approximately 120 days postpartum. (3) A similar increased responsiveness of the hypothalamic-pituitary axis controlling prolactin secretion in postpartum females is manifested by the suckling response and increased prolactin response to thyrotrophin releasing hormone (TRH). The time course of normalization of these enhanced endocrine responses is roughly similar to that found for normalization of the prolactin response to neuroleptic drugs. A common mechanism may underlie each of these phenomena.
AB - (1) Serum prolactin levels of six women, who developed psychoses during the postpartum period and were treated with neuroleptic drugs, were higher than those of a group of non-postpartum women of comparable age treated with similar doses of these drugs. (2) The magnitude of the neuroleptic-induced elevations in serum prolactin diminished with time during the postpartum period and returned to that found in non-parturient drug-treated females approximately 120 days postpartum. (3) A similar increased responsiveness of the hypothalamic-pituitary axis controlling prolactin secretion in postpartum females is manifested by the suckling response and increased prolactin response to thyrotrophin releasing hormone (TRH). The time course of normalization of these enhanced endocrine responses is roughly similar to that found for normalization of the prolactin response to neuroleptic drugs. A common mechanism may underlie each of these phenomena.
UR - http://www.scopus.com/inward/record.url?scp=0019159119&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019159119&partnerID=8YFLogxK
U2 - 10.1016/0306-4530(80)90038-4
DO - 10.1016/0306-4530(80)90038-4
M3 - Article
C2 - 6111101
AN - SCOPUS:0019159119
VL - 5
SP - 345
EP - 351
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
SN - 0306-4530
IS - 4
ER -