Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats

Diosely C. Silveira*, Gregory L. Holmes, Steven C. Schachter, Changiz Geula, Donald L. Schomer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)223-227
Number of pages5
JournalBrain research
Volume878
Issue number1-2
DOIs
StatePublished - Sep 29 2000

Keywords

  • Cholinergic system
  • Epilepsy
  • Flurothyl
  • Pentylenetetrazole
  • Saporin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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