Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats

Diosely C. Silveira; Gregory L. Holmes; Steven C. Schachter; Changiz Geula; Donald L. Schomer

doi:10.1016/S0006-8993(00)02703-7

Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats

Diosely C. Silveira^*, Gregory L. Holmes, Steven C. Schachter, Changiz Geula, Donald L. Schomer

^*Corresponding author for this work

Mesulam Center for Cognitive Neurology and Alzheimers Disease

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures. (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	223-227
Number of pages	5
Journal	Brain research
Volume	878
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(00)02703-7
State	Published - Sep 29 2000

Funding

This work was supported by NIH grant (NS27984) to GLH and the Emily P. Rogers Research Fund.

Keywords

Cholinergic system
Epilepsy
Flurothyl
Pentylenetetrazole
Saporin

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

Access to Document

10.1016/S0006-8993(00)02703-7

Cite this

@article{c42deff5adbc4203b2b5e7b04d29c01e,

title = "Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats",

abstract = "We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures. (C) 2000 Elsevier Science B.V.",

keywords = "Cholinergic system, Epilepsy, Flurothyl, Pentylenetetrazole, Saporin",

author = "Silveira, {Diosely C.} and Holmes, {Gregory L.} and Schachter, {Steven C.} and Changiz Geula and Schomer, {Donald L.}",

note = "Funding Information: This work was supported by NIH grant (NS27984) to GLH and the Emily P. Rogers Research Fund.",

year = "2000",

month = sep,

day = "29",

doi = "10.1016/S0006-8993(00)02703-7",

language = "English (US)",

volume = "878",

pages = "223--227",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats

AU - Silveira, Diosely C.

AU - Holmes, Gregory L.

AU - Schachter, Steven C.

AU - Geula, Changiz

AU - Schomer, Donald L.

N1 - Funding Information: This work was supported by NIH grant (NS27984) to GLH and the Emily P. Rogers Research Fund.

PY - 2000/9/29

Y1 - 2000/9/29

N2 - We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures. (C) 2000 Elsevier Science B.V.

AB - We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures. (C) 2000 Elsevier Science B.V.

KW - Cholinergic system

KW - Epilepsy

KW - Flurothyl

KW - Pentylenetetrazole

KW - Saporin

UR - http://www.scopus.com/inward/record.url?scp=0034730687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034730687&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(00)02703-7

DO - 10.1016/S0006-8993(00)02703-7

M3 - Article

C2 - 10996157

AN - SCOPUS:0034730687

SN - 0006-8993

VL - 878

SP - 223

EP - 227

JO - Brain research

JF - Brain research

IS - 1-2

ER -

Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this