Increased telomerase activity is associated with shorter survival in patients with chronic phase chronic myeloid leukemia

Srdan Verstovsek, Hagop Kantarjian, Taghi Manshouri, Jorge Cortes, Stefan Faderl, Francis J. Giles, Michael Keating, Maher Albitar*

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

BACKGROUND. Significantly elevated telomerase activity (TA) has been found in samples from patients with many malignant hematologic diseases. However, the impact of elevated TA on the course of patients with chronic phase chronic myeloid leukemia (CP-CML) is unknown. METHODS. Using a modified polymerase chain reaction-based telomeric repeat amplification protocol assay, the authors measured TA in bone marrow samples from 93 patients with CP-CML and correlated it with patient characteristics and survival. TA also was measured in bone marrow samples from 29 patients with accelerated/blastic phase CML. RESULTS. Patients with accelerated/blastic phase CML were found to have some-what higher levels of TA compared with patients with CP-CML (P = 0.07). Among patients with CP-CML, those with high TA progressed to advanced stages of disease sooner (P = 0.05) and had a significantly shorter survival (P = 0.04) than patients with low TA. No correlation was found between TA and patient age, hemoglobin, platelet and leukocyte counts, percentage of peripheral or bone marrow blasts or basophils, or bone marrow cellularity. On multivariate analysis, high TA retained its significance as a factor associated with shorter patient survival (P = 0.02). CONCLUSIONS. The current study data suggest that TA plays a role in the propagation of CP-CML and that the potential of telomerase inhibitors in patients with CML should be explored, even in those with early phase disease.

Original languageEnglish (US)
Pages (from-to)1248-1252
Number of pages5
JournalCancer
Volume97
Issue number5
DOIs
StatePublished - Mar 1 2003

Keywords

  • Accelerated/blastic phase chronic myeloid leukemia (A/BP-CML)
  • Chronic phase chronic myeloidleukemia (CP-CML)
  • Prognosis
  • Telomerase activity (TA)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Increased telomerase activity is associated with shorter survival in patients with chronic phase chronic myeloid leukemia'. Together they form a unique fingerprint.

  • Cite this

    Verstovsek, S., Kantarjian, H., Manshouri, T., Cortes, J., Faderl, S., Giles, F. J., Keating, M., & Albitar, M. (2003). Increased telomerase activity is associated with shorter survival in patients with chronic phase chronic myeloid leukemia. Cancer, 97(5), 1248-1252. https://doi.org/10.1002/cncr.11217