TY - JOUR
T1 - Increases in Neuroticism May Be an Early Indicator of Dementia
T2 - A Coordinated Analysis
AU - Yoneda, Tomiko
AU - Rush, Jonathan
AU - Graham, Eileen K.
AU - Berg, Anne Ingeborg
AU - Comijs, Hannie
AU - Katz, Mindy
AU - Lipton, Richard B.
AU - Johansson, Boo
AU - Mroczek, Daniel K.
AU - Piccinin, Andrea M.
N1 - Funding Information:
This work was supported by the National Institute on Aging (NIA) at the National Institutes of Health (NIH; grant number P01AG043362; 2013–2018) in support of the Integrative Analysis of Longitudinal Studies of Aging (IALSA) research network. Origins of Variance in the Oldest-Old (OCTO-Twin) data collection was funded by the National Institute on Aging at the National Institutes of Health (grant number AG08861); the Swedish Council for Working Life and Social Research; the Adlerbertska Foundation; the Wenner-Gren Foundations; and the Wilhelm and Martina Lundgrens Foundation. The Longitudinal Aging Study Amsterdam (LASA) is largely supported by the Netherlands Ministry of Health, Welfare and Sports, Directorate of Long-Term Care. Einstein Aging Study (EAS) data collection was supported by the National Institutes of Health NIA (National Institute on Aging) Grant AG03949; the Sylvia & Leonard Marx Foundation, and; the Czap Foundation. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official view of the NIH.
Publisher Copyright:
© 2018 The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.
PY - 2020/1/14
Y1 - 2020/1/14
N2 - Objectives: Although personality change is typically considered a symptom of dementia, some studies suggest that personality change may be an early indication of dementia. One prospective study found increases in neuroticism preceding dementia diagnosis (Yoneda, T., Rush, J., Berg, A. I., Johansson, B., & Piccinin, A. M. (2017). Trajectories of personality traits preceding dementia diagnosis. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 72, 922-931. doi:10.1093/geronb/gbw006). This study extends this research by examining trajectories of personality traits in additional longitudinal studies of aging. Methods: Three independent series of latent growth curve models were fitted to data from the Longitudinal Aging Study Amsterdam and Einstein Aging Study to estimate trajectories of personality traits in individuals with incident dementia diagnosis (total N = 210), in individuals with incident Mild Cognitive Impairment (N = 135), and in individuals who did not receive a diagnosis during follow-up periods (total N = 1740). Results: Controlling for sex, age, education, depressive symptoms, and the interaction between age and education, growth curve analyses consistently revealed significant linear increases in neuroticism preceding dementia diagnosis in both datasets and in individuals with mild cognitive impairment. Analyses examining individuals without a diagnosis revealed nonsignificant change in neuroticism overtime. Discussion: Replication of our previous work in 2 additional datasets provides compelling evidence that increases in neuroticism may be early indication of dementia, which can facilitate development of screening assessments.
AB - Objectives: Although personality change is typically considered a symptom of dementia, some studies suggest that personality change may be an early indication of dementia. One prospective study found increases in neuroticism preceding dementia diagnosis (Yoneda, T., Rush, J., Berg, A. I., Johansson, B., & Piccinin, A. M. (2017). Trajectories of personality traits preceding dementia diagnosis. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 72, 922-931. doi:10.1093/geronb/gbw006). This study extends this research by examining trajectories of personality traits in additional longitudinal studies of aging. Methods: Three independent series of latent growth curve models were fitted to data from the Longitudinal Aging Study Amsterdam and Einstein Aging Study to estimate trajectories of personality traits in individuals with incident dementia diagnosis (total N = 210), in individuals with incident Mild Cognitive Impairment (N = 135), and in individuals who did not receive a diagnosis during follow-up periods (total N = 1740). Results: Controlling for sex, age, education, depressive symptoms, and the interaction between age and education, growth curve analyses consistently revealed significant linear increases in neuroticism preceding dementia diagnosis in both datasets and in individuals with mild cognitive impairment. Analyses examining individuals without a diagnosis revealed nonsignificant change in neuroticism overtime. Discussion: Replication of our previous work in 2 additional datasets provides compelling evidence that increases in neuroticism may be early indication of dementia, which can facilitate development of screening assessments.
KW - Longitudinal change
KW - Mild cognitive impairment
KW - Multi-study conceptual replication
KW - Personality
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U2 - 10.1093/geronb/gby034
DO - 10.1093/geronb/gby034
M3 - Article
C2 - 29608748
AN - SCOPUS:85077940759
VL - 75
SP - 251
EP - 262
JO - Journals of Gerontology - Series B Psychological Sciences and Social Sciences
JF - Journals of Gerontology - Series B Psychological Sciences and Social Sciences
SN - 1079-5014
IS - 2
ER -