Increasing incidence of linezolid-intermediate or -resistant, vancomycin-resistant Enterococcus faecium strains parallels increasing linezolid consumption

Marc H. Scheetz, Stephanie A. Knechtel, Michael Malczynski, Michael J. Postelnick, Chao Qi

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Clinical enterococcal resistance to linezolid is defined by the presence of the G2576T mutation. We evaluated the incidence of genetically proven linezolid resistance among vancomycin-resistant Enterococcus faecium strains and linezolid consumption for a possible association. A relationship was found (r2 = 0.73, P = 0.03) and predicts increasing resistance with current trends of linezolid use.

Original languageEnglish (US)
Pages (from-to)2256-2259
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume52
Issue number6
DOIs
StatePublished - Jun 2008

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology

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