Increasing the speed limit for hole transport in DNA

Arun K. Thazhathveetil, Anton Trifonov, Michael R. Wasielewski*, Frederick D. Lewis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Transport of positive charge or holes in DNA occurs via a thermally activated multi-step hopping mechanism. The fastest hopping rates reported to date are those for repeating poly(purine) sequences in which hopping occurs via a random walk mechanism with rate constants of k hop = 4.3 ×10 9 s -1 for poly(dG) and 1.2 ×10 9 s -1 for poly(dA). We report here the dynamics of charge separation in DNA conjugates possessing repeating 7-deazaadenine (dzA) sequences. These data provide an estimated value of k hop = 4.2 ×10 10 s -1 for poly(dzA), an order of magnitude faster than for poly(dG).

Original languageEnglish (US)
Pages (from-to)11485-11487
Number of pages3
JournalJournal of the American Chemical Society
Issue number30
StatePublished - Aug 3 2011

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry


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