Increasing the speed limit for hole transport in DNA

Arun K. Thazhathveetil; Anton Trifonov; Michael R Wasielewski; Frederick D Lewis

doi:10.1021/ja204815d

Increasing the speed limit for hole transport in DNA

Arun K. Thazhathveetil, Anton Trifonov, Michael R Wasielewski^*, Frederick D Lewis

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Transport of positive charge or holes in DNA occurs via a thermally activated multi-step hopping mechanism. The fastest hopping rates reported to date are those for repeating poly(purine) sequences in which hopping occurs via a random walk mechanism with rate constants of k _hop = 4.3 ×10 ⁹ s ^-1 for poly(dG) and 1.2 ×10 ⁹ s ^-1 for poly(dA). We report here the dynamics of charge separation in DNA conjugates possessing repeating 7-deazaadenine (dzA) sequences. These data provide an estimated value of k _hop = 4.2 ×10 ¹⁰ s ^-1 for poly(dzA), an order of magnitude faster than for poly(dG).

Original language	English (US)
Pages (from-to)	11485-11487
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	133
Issue number	30
DOIs	https://doi.org/10.1021/ja204815d
State	Published - Aug 3 2011

ASJC Scopus subject areas

Chemistry(all)
Catalysis
Biochemistry
Colloid and Surface Chemistry

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title = "Increasing the speed limit for hole transport in DNA",

abstract = "Transport of positive charge or holes in DNA occurs via a thermally activated multi-step hopping mechanism. The fastest hopping rates reported to date are those for repeating poly(purine) sequences in which hopping occurs via a random walk mechanism with rate constants of k hop = 4.3 ×10 9 s -1 for poly(dG) and 1.2 ×10 9 s -1 for poly(dA). We report here the dynamics of charge separation in DNA conjugates possessing repeating 7-deazaadenine (dzA) sequences. These data provide an estimated value of k hop = 4.2 ×10 10 s -1 for poly(dzA), an order of magnitude faster than for poly(dG).",

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AB - Transport of positive charge or holes in DNA occurs via a thermally activated multi-step hopping mechanism. The fastest hopping rates reported to date are those for repeating poly(purine) sequences in which hopping occurs via a random walk mechanism with rate constants of k hop = 4.3 ×10 9 s -1 for poly(dG) and 1.2 ×10 9 s -1 for poly(dA). We report here the dynamics of charge separation in DNA conjugates possessing repeating 7-deazaadenine (dzA) sequences. These data provide an estimated value of k hop = 4.2 ×10 10 s -1 for poly(dzA), an order of magnitude faster than for poly(dG).

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