Increasing the speed limit for hole transport in DNA

Arun K. Thazhathveetil; Anton Trifonov; Michael R Wasielewski; Frederick D Lewis

doi:10.1021/ja204815d

Increasing the speed limit for hole transport in DNA

Arun K. Thazhathveetil, Anton Trifonov, Michael R Wasielewski^*, Frederick D Lewis

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Transport of positive charge or holes in DNA occurs via a thermally activated multi-step hopping mechanism. The fastest hopping rates reported to date are those for repeating poly(purine) sequences in which hopping occurs via a random walk mechanism with rate constants of k _hop = 4.3 ×10 ⁹ s ^-1 for poly(dG) and 1.2 ×10 ⁹ s ^-1 for poly(dA). We report here the dynamics of charge separation in DNA conjugates possessing repeating 7-deazaadenine (dzA) sequences. These data provide an estimated value of k _hop = 4.2 ×10 ¹⁰ s ^-1 for poly(dzA), an order of magnitude faster than for poly(dG).

Original language	English (US)
Pages (from-to)	11485-11487
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	133
Issue number	30
DOIs	https://doi.org/10.1021/ja204815d
State	Published - Aug 3 2011

ASJC Scopus subject areas

Chemistry(all)
Catalysis
Biochemistry
Colloid and Surface Chemistry

Access to Document

10.1021/ja204815d

Cite this

@article{1e4dc403d83e403dbcaecde832342cb9,

title = "Increasing the speed limit for hole transport in DNA",

abstract = "Transport of positive charge or holes in DNA occurs via a thermally activated multi-step hopping mechanism. The fastest hopping rates reported to date are those for repeating poly(purine) sequences in which hopping occurs via a random walk mechanism with rate constants of k hop = 4.3 ×10 9 s -1 for poly(dG) and 1.2 ×10 9 s -1 for poly(dA). We report here the dynamics of charge separation in DNA conjugates possessing repeating 7-deazaadenine (dzA) sequences. These data provide an estimated value of k hop = 4.2 ×10 10 s -1 for poly(dzA), an order of magnitude faster than for poly(dG).",

author = "Thazhathveetil, {Arun K.} and Anton Trifonov and Wasielewski, {Michael R} and Lewis, {Frederick D}",

year = "2011",

month = aug,

day = "3",

doi = "10.1021/ja204815d",

language = "English (US)",

volume = "133",

pages = "11485--11487",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "30",

}

TY - JOUR

T1 - Increasing the speed limit for hole transport in DNA

AU - Thazhathveetil, Arun K.

AU - Trifonov, Anton

AU - Wasielewski, Michael R

AU - Lewis, Frederick D

PY - 2011/8/3

Y1 - 2011/8/3

N2 - Transport of positive charge or holes in DNA occurs via a thermally activated multi-step hopping mechanism. The fastest hopping rates reported to date are those for repeating poly(purine) sequences in which hopping occurs via a random walk mechanism with rate constants of k hop = 4.3 ×10 9 s -1 for poly(dG) and 1.2 ×10 9 s -1 for poly(dA). We report here the dynamics of charge separation in DNA conjugates possessing repeating 7-deazaadenine (dzA) sequences. These data provide an estimated value of k hop = 4.2 ×10 10 s -1 for poly(dzA), an order of magnitude faster than for poly(dG).

AB - Transport of positive charge or holes in DNA occurs via a thermally activated multi-step hopping mechanism. The fastest hopping rates reported to date are those for repeating poly(purine) sequences in which hopping occurs via a random walk mechanism with rate constants of k hop = 4.3 ×10 9 s -1 for poly(dG) and 1.2 ×10 9 s -1 for poly(dA). We report here the dynamics of charge separation in DNA conjugates possessing repeating 7-deazaadenine (dzA) sequences. These data provide an estimated value of k hop = 4.2 ×10 10 s -1 for poly(dzA), an order of magnitude faster than for poly(dG).

UR - http://www.scopus.com/inward/record.url?scp=79960875177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960875177&partnerID=8YFLogxK

U2 - 10.1021/ja204815d

DO - 10.1021/ja204815d

M3 - Article

C2 - 21728369

AN - SCOPUS:79960875177

VL - 133

SP - 11485

EP - 11487

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 30

ER -

Increasing the speed limit for hole transport in DNA

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this