Indications and complications of transfusions in sickle cell disease

Kim Smith-Whitley*, Alexis A Thompson

*Corresponding author for this work

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Red cell transfusion remains an important part of the management of acute and chronic complications in SCD. The ongoing and emerging uses of transfusions in SCD may have significant benefits; however, the potential complications of transfusions also deserve careful consideration. In this report we review current indications for transfusions, transfusion complications, modifications of transfusion practices to mitigate risk, and potential considerations to improve transfusion outcomes.

Original languageEnglish (US)
Pages (from-to)358-364
Number of pages7
JournalPediatric Blood and Cancer
Volume59
Issue number2
DOIs
StatePublished - Aug 1 2012

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Sickle Cell Anemia

Keywords

  • Alloimmunization
  • Red cell transfusion indications
  • Sickle cell disease
  • Transfusional iron overload

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

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Indications and complications of transfusions in sickle cell disease. / Smith-Whitley, Kim; Thompson, Alexis A.

In: Pediatric Blood and Cancer, Vol. 59, No. 2, 01.08.2012, p. 358-364.

Research output: Contribution to journalReview article

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T1 - Indications and complications of transfusions in sickle cell disease

AU - Smith-Whitley, Kim

AU - Thompson, Alexis A

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Red cell transfusion remains an important part of the management of acute and chronic complications in SCD. The ongoing and emerging uses of transfusions in SCD may have significant benefits; however, the potential complications of transfusions also deserve careful consideration. In this report we review current indications for transfusions, transfusion complications, modifications of transfusion practices to mitigate risk, and potential considerations to improve transfusion outcomes.

AB - Red cell transfusion remains an important part of the management of acute and chronic complications in SCD. The ongoing and emerging uses of transfusions in SCD may have significant benefits; however, the potential complications of transfusions also deserve careful consideration. In this report we review current indications for transfusions, transfusion complications, modifications of transfusion practices to mitigate risk, and potential considerations to improve transfusion outcomes.

KW - Alloimmunization

KW - Red cell transfusion indications

KW - Sickle cell disease

KW - Transfusional iron overload

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DO - 10.1002/pbc.24179

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