Indications and complications of transfusions in sickle cell disease

Kim Smith-Whitley*, Alexis A Thompson

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Red cell transfusion remains an important part of the management of acute and chronic complications in SCD. The ongoing and emerging uses of transfusions in SCD may have significant benefits; however, the potential complications of transfusions also deserve careful consideration. In this report we review current indications for transfusions, transfusion complications, modifications of transfusion practices to mitigate risk, and potential considerations to improve transfusion outcomes.

Original languageEnglish (US)
Pages (from-to)358-364
Number of pages7
JournalPediatric Blood and Cancer
Issue number2
StatePublished - Aug 1 2012


  • Alloimmunization
  • Red cell transfusion indications
  • Sickle cell disease
  • Transfusional iron overload

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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