Indications and results of liver resection and hepatic chemoembolization for metastatic gastrointestinal neuroendocrine tumors

Katherine A. Yao, Mark S. Talamonti, Albert A Nemcek Jr, Peter Angelos, Howard B Chrisman, Janet Skarda, Al B Benson III, Sambasiva Rao Musunuri, Raymond J. Joehl

Research output: Contribution to journalArticle

183 Scopus citations


Background. We reviewed 36 patients with liver metastases from islet cell tumors of the pancreas (n = 18) and carcinoid tumors (n = 18) who were treated with surgical resection (n = 16) or hepatic chemoembolization (n = 20). Methods. All resections were complete and included 4 lobectomies, 6 segmental resections, and 6 wedge resections. There were no operative deaths. Results. Median survival has not yet been reached, and the actuarial 5-year survival rate is 70%. Prognostic variables associated with improved disease-free survival included prior resection of the primary tumor and 4 or fewer metastases resected (P <.05). With an average of 3 chemoembolization procedures per patient, 17 of 20 patients (90%) demonstrated either a significant radiographic response (n = 5), stabilization of tumor mass (n = 2), or improvement of clinical symptoms (n = 10). Factors related to a sustained response (more then 1 year) included surgical resection of the primary tumor, 4 or more chemoembolization procedures, and liver metastases of 5 cm or smaller. Median survival after treatment was 32 months (range, 7-63 months), and the actuarial 5-year survival rate was 40%. Conclusions. Surgical resection of metastatic neuroendocrine tumors provides the best chance for extended survival. Chemoembolization effectively improves clinical symptoms and, in selected patients, may provide sustained tumor control.

Original languageEnglish (US)
Pages (from-to)677-685
Number of pages9
Issue number4
StatePublished - Jan 1 2001


ASJC Scopus subject areas

  • Surgery

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