Indicators of Lung Shunt Fraction Determined by Technetium-99 m Macroaggregated Albumin in Patients with Hepatocellular Carcinoma

Joseph Ralph Kallini, Ahmed Gabr, Ryan Hickey, Laura M Kulik, Kush R Desai, Yihe Yang, Vanessa L. Gates, Ahsun Riaz, Riad Salem, Robert J Lewandowski*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To determine the correlation of pre-procedural and imaging characteristics with lung shunt fraction (LSF) measured by technetium-99 m macroaggregated albumin (99mTc-MAA) scan in patients with hepatocellular carcinoma. Methods: A retrospective study was conducted of 428 subjects with hepatocellular carcinoma from 2004 to 2011 assessed for lung shunting by 99mTc-MAA scan. Baseline characteristics included age, gender, ethnicity, tumor burden, maximum dimension, number of lesions, presence of extrahepatic metastases, macrovascular (hepatic and portal vein) invasion, ascites on imaging, laboratory values, and alpha-fetoprotein (AFP). Univariate and multivariate logistic regression analysis was performed. Receiver operating characteristic curves were used to obtain sensitivity (SN), specificity (SP), and positive likelihood ratios (LR+) of characteristics for low LSF (LSF <10%) and high LSF (LSF >20%). Results: Statistically significant (p < 0.05) independent indicators of low LSF included bilirubin <1.45 mg/dL (SN = 49.5%, SP = 69.1%, LR+ = 1.60), maximum tumor size <7.15 cm (SN = 66.0%, SP = 75.9%, LR+ = 2.74), AFP ≤200 ng/mL (SN = 64.6%, SP = 65.0%, LR+ = 1.85), and absent macrovascular invasion (SN = 73.9%, SP = 64.9%, LR+ = 2.11). Independent indicators of high LSF included albumin <2.65 g/dL (SN = 64.3%, SP = 64.1%, LR+ = 1.79) and macrovascular invasion (SN = 74.4%, SP = 67.4%, LR+ = 2.28). A combined risk factor model was constructed. If there is no macrovascular invasion: LSF=e-3.846×(Bilirubin)0.303×AFP0.056×(Maximum dimension)0.364. With macrovascular invasion, LSF=e-3.629×(Bilirubin)0.303×AFP0.056×(Maximum dimension)0.364 (R2 = 0.257). Since these factors all have LR+ between 2 and 5, they only reflect slight increase in LSF predictivity. Conclusion: Serum AFP, albumin, bilirubin, and portal/hepatic vein invasion on cross-sectional imaging are statistically significant but weak clinical indicators of LSF, as shown by low SN, SP, and LR+ for clinically relevant cutoff LSF values. Thus, these factors cannot be relied upon in clinical practice.

Original languageEnglish (US)
Pages (from-to)1213-1222
Number of pages10
JournalCardioVascular and Interventional Radiology
Volume40
Issue number8
DOIs
StatePublished - Aug 1 2017

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Technetium
Albumins
Hepatocellular Carcinoma
Lung
Sensitivity and Specificity
Bilirubin
alpha-Fetoproteins
Hepatic Veins
Portal Vein
Tumor Burden
Ascites
ROC Curve
Retrospective Studies
Logistic Models
Regression Analysis
Neoplasm Metastasis

Keywords

  • Hepatocellular carcinoma (HCC)
  • Hepatopulmonary shunt
  • Lung shunt fraction (LSF)
  • Radioembolization
  • Risk factors
  • Technetium-99 m macroaggregated albumin (Tc-MAA)
  • Yttrium-90

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

@article{01f62ee566e94d6391fbf51c48a35c6a,
title = "Indicators of Lung Shunt Fraction Determined by Technetium-99 m Macroaggregated Albumin in Patients with Hepatocellular Carcinoma",
abstract = "Purpose: To determine the correlation of pre-procedural and imaging characteristics with lung shunt fraction (LSF) measured by technetium-99 m macroaggregated albumin (99mTc-MAA) scan in patients with hepatocellular carcinoma. Methods: A retrospective study was conducted of 428 subjects with hepatocellular carcinoma from 2004 to 2011 assessed for lung shunting by 99mTc-MAA scan. Baseline characteristics included age, gender, ethnicity, tumor burden, maximum dimension, number of lesions, presence of extrahepatic metastases, macrovascular (hepatic and portal vein) invasion, ascites on imaging, laboratory values, and alpha-fetoprotein (AFP). Univariate and multivariate logistic regression analysis was performed. Receiver operating characteristic curves were used to obtain sensitivity (SN), specificity (SP), and positive likelihood ratios (LR+) of characteristics for low LSF (LSF <10{\%}) and high LSF (LSF >20{\%}). Results: Statistically significant (p < 0.05) independent indicators of low LSF included bilirubin <1.45 mg/dL (SN = 49.5{\%}, SP = 69.1{\%}, LR+ = 1.60), maximum tumor size <7.15 cm (SN = 66.0{\%}, SP = 75.9{\%}, LR+ = 2.74), AFP ≤200 ng/mL (SN = 64.6{\%}, SP = 65.0{\%}, LR+ = 1.85), and absent macrovascular invasion (SN = 73.9{\%}, SP = 64.9{\%}, LR+ = 2.11). Independent indicators of high LSF included albumin <2.65 g/dL (SN = 64.3{\%}, SP = 64.1{\%}, LR+ = 1.79) and macrovascular invasion (SN = 74.4{\%}, SP = 67.4{\%}, LR+ = 2.28). A combined risk factor model was constructed. If there is no macrovascular invasion: LSF=e-3.846×(Bilirubin)0.303×AFP0.056×(Maximum dimension)0.364. With macrovascular invasion, LSF=e-3.629×(Bilirubin)0.303×AFP0.056×(Maximum dimension)0.364 (R2 = 0.257). Since these factors all have LR+ between 2 and 5, they only reflect slight increase in LSF predictivity. Conclusion: Serum AFP, albumin, bilirubin, and portal/hepatic vein invasion on cross-sectional imaging are statistically significant but weak clinical indicators of LSF, as shown by low SN, SP, and LR+ for clinically relevant cutoff LSF values. Thus, these factors cannot be relied upon in clinical practice.",
keywords = "Hepatocellular carcinoma (HCC), Hepatopulmonary shunt, Lung shunt fraction (LSF), Radioembolization, Risk factors, Technetium-99 m macroaggregated albumin (Tc-MAA), Yttrium-90",
author = "Kallini, {Joseph Ralph} and Ahmed Gabr and Ryan Hickey and Kulik, {Laura M} and Desai, {Kush R} and Yihe Yang and Gates, {Vanessa L.} and Ahsun Riaz and Riad Salem and Lewandowski, {Robert J}",
year = "2017",
month = "8",
day = "1",
doi = "10.1007/s00270-017-1619-z",
language = "English (US)",
volume = "40",
pages = "1213--1222",
journal = "CardioVascular and Interventional Radiology",
issn = "7415-5101",
publisher = "Springer Verlag",
number = "8",

}

Indicators of Lung Shunt Fraction Determined by Technetium-99 m Macroaggregated Albumin in Patients with Hepatocellular Carcinoma. / Kallini, Joseph Ralph; Gabr, Ahmed; Hickey, Ryan; Kulik, Laura M; Desai, Kush R; Yang, Yihe; Gates, Vanessa L.; Riaz, Ahsun; Salem, Riad; Lewandowski, Robert J.

In: CardioVascular and Interventional Radiology, Vol. 40, No. 8, 01.08.2017, p. 1213-1222.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Indicators of Lung Shunt Fraction Determined by Technetium-99 m Macroaggregated Albumin in Patients with Hepatocellular Carcinoma

AU - Kallini, Joseph Ralph

AU - Gabr, Ahmed

AU - Hickey, Ryan

AU - Kulik, Laura M

AU - Desai, Kush R

AU - Yang, Yihe

AU - Gates, Vanessa L.

AU - Riaz, Ahsun

AU - Salem, Riad

AU - Lewandowski, Robert J

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Purpose: To determine the correlation of pre-procedural and imaging characteristics with lung shunt fraction (LSF) measured by technetium-99 m macroaggregated albumin (99mTc-MAA) scan in patients with hepatocellular carcinoma. Methods: A retrospective study was conducted of 428 subjects with hepatocellular carcinoma from 2004 to 2011 assessed for lung shunting by 99mTc-MAA scan. Baseline characteristics included age, gender, ethnicity, tumor burden, maximum dimension, number of lesions, presence of extrahepatic metastases, macrovascular (hepatic and portal vein) invasion, ascites on imaging, laboratory values, and alpha-fetoprotein (AFP). Univariate and multivariate logistic regression analysis was performed. Receiver operating characteristic curves were used to obtain sensitivity (SN), specificity (SP), and positive likelihood ratios (LR+) of characteristics for low LSF (LSF <10%) and high LSF (LSF >20%). Results: Statistically significant (p < 0.05) independent indicators of low LSF included bilirubin <1.45 mg/dL (SN = 49.5%, SP = 69.1%, LR+ = 1.60), maximum tumor size <7.15 cm (SN = 66.0%, SP = 75.9%, LR+ = 2.74), AFP ≤200 ng/mL (SN = 64.6%, SP = 65.0%, LR+ = 1.85), and absent macrovascular invasion (SN = 73.9%, SP = 64.9%, LR+ = 2.11). Independent indicators of high LSF included albumin <2.65 g/dL (SN = 64.3%, SP = 64.1%, LR+ = 1.79) and macrovascular invasion (SN = 74.4%, SP = 67.4%, LR+ = 2.28). A combined risk factor model was constructed. If there is no macrovascular invasion: LSF=e-3.846×(Bilirubin)0.303×AFP0.056×(Maximum dimension)0.364. With macrovascular invasion, LSF=e-3.629×(Bilirubin)0.303×AFP0.056×(Maximum dimension)0.364 (R2 = 0.257). Since these factors all have LR+ between 2 and 5, they only reflect slight increase in LSF predictivity. Conclusion: Serum AFP, albumin, bilirubin, and portal/hepatic vein invasion on cross-sectional imaging are statistically significant but weak clinical indicators of LSF, as shown by low SN, SP, and LR+ for clinically relevant cutoff LSF values. Thus, these factors cannot be relied upon in clinical practice.

AB - Purpose: To determine the correlation of pre-procedural and imaging characteristics with lung shunt fraction (LSF) measured by technetium-99 m macroaggregated albumin (99mTc-MAA) scan in patients with hepatocellular carcinoma. Methods: A retrospective study was conducted of 428 subjects with hepatocellular carcinoma from 2004 to 2011 assessed for lung shunting by 99mTc-MAA scan. Baseline characteristics included age, gender, ethnicity, tumor burden, maximum dimension, number of lesions, presence of extrahepatic metastases, macrovascular (hepatic and portal vein) invasion, ascites on imaging, laboratory values, and alpha-fetoprotein (AFP). Univariate and multivariate logistic regression analysis was performed. Receiver operating characteristic curves were used to obtain sensitivity (SN), specificity (SP), and positive likelihood ratios (LR+) of characteristics for low LSF (LSF <10%) and high LSF (LSF >20%). Results: Statistically significant (p < 0.05) independent indicators of low LSF included bilirubin <1.45 mg/dL (SN = 49.5%, SP = 69.1%, LR+ = 1.60), maximum tumor size <7.15 cm (SN = 66.0%, SP = 75.9%, LR+ = 2.74), AFP ≤200 ng/mL (SN = 64.6%, SP = 65.0%, LR+ = 1.85), and absent macrovascular invasion (SN = 73.9%, SP = 64.9%, LR+ = 2.11). Independent indicators of high LSF included albumin <2.65 g/dL (SN = 64.3%, SP = 64.1%, LR+ = 1.79) and macrovascular invasion (SN = 74.4%, SP = 67.4%, LR+ = 2.28). A combined risk factor model was constructed. If there is no macrovascular invasion: LSF=e-3.846×(Bilirubin)0.303×AFP0.056×(Maximum dimension)0.364. With macrovascular invasion, LSF=e-3.629×(Bilirubin)0.303×AFP0.056×(Maximum dimension)0.364 (R2 = 0.257). Since these factors all have LR+ between 2 and 5, they only reflect slight increase in LSF predictivity. Conclusion: Serum AFP, albumin, bilirubin, and portal/hepatic vein invasion on cross-sectional imaging are statistically significant but weak clinical indicators of LSF, as shown by low SN, SP, and LR+ for clinically relevant cutoff LSF values. Thus, these factors cannot be relied upon in clinical practice.

KW - Hepatocellular carcinoma (HCC)

KW - Hepatopulmonary shunt

KW - Lung shunt fraction (LSF)

KW - Radioembolization

KW - Risk factors

KW - Technetium-99 m macroaggregated albumin (Tc-MAA)

KW - Yttrium-90

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U2 - 10.1007/s00270-017-1619-z

DO - 10.1007/s00270-017-1619-z

M3 - Article

C2 - 28280976

AN - SCOPUS:85014583675

VL - 40

SP - 1213

EP - 1222

JO - CardioVascular and Interventional Radiology

JF - CardioVascular and Interventional Radiology

SN - 7415-5101

IS - 8

ER -