Indirect protection of adults from rotavirus by pediatric rotavirus vaccination

Evan J. Anderson*, Deanna B. Shippee, Melissa H. Weinrobe, Melissa Danyella Bregger, Ben Z Katz, Susheel Reddy, Mary Gene Karen P Cuyugan, Samuel Y. Lee, Yael M. Simons, Ram Yogev, Gary A Noskin

*Corresponding author for this work

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Background. Pediatric vaccination has resulted in declines in disease in unvaccinated individuals through decreasing pathogen circulation in the community. About 2 years after implementation of pediatric rotavirus vaccination in the United States, dramatic declines in rotavirus disease were observed in both vaccinated and unvaccinated children. Whether this protection extends to adults is unknown. Methods. The prevalence of rotavirus, as determined by Rotaclone enzyme immunoassay, in adults who had stools submitted for bacterial stool culture (BSC) between February to May to Northwestern Memorial Hospital, Chicago, was compared between the prepediatric impact era (2006-2007) and the pediatric impact era (2008-2010). Isolates were genotyped and clinical characteristics of those with rotavirus were compared. Results. Of the 5788 BSC sent, 4725 met inclusion criteria and 3530 of these (74.7%) were saved for rotavirus testing. The prevalence of rotavirus among adults who had stool sent for BSC declined from 4.35% in 2006-2007 to 2.24% in 2008-2010 (a relative decline of 48.4%; P =. 0007). The decline in the prevalence of rotavirus was of similar significant magnitude in both outpatients and inpatients. Marked year-to-year variability was observed in circulating rotavirus genotypes, with strain G2P[4] accounting for 24%; G1P[8], 22%; G3P[8], 11%; and G12P[6], 10% overall. About 30% of adults from whom rotavirus was isolated were immunocompromised and this remained constant. Conclusions. Pediatric rotavirus vaccination correlated with a relative decline of almost 50% in rotavirus identified from adult BSC during the peak rotavirus season, suggesting that pediatric rotavirus vaccination protects adults from rotavirus.

Original languageEnglish (US)
Pages (from-to)755-760
Number of pages6
JournalClinical Infectious Diseases
Volume56
Issue number6
DOIs
StatePublished - Mar 15 2013

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Rotavirus
Vaccination
Pediatrics
Immunoenzyme Techniques
Inpatients

Keywords

  • adult
  • genotypes
  • indirect protection
  • pediatric
  • rotavirus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Anderson, Evan J. ; Shippee, Deanna B. ; Weinrobe, Melissa H. ; Bregger, Melissa Danyella ; Katz, Ben Z ; Reddy, Susheel ; Cuyugan, Mary Gene Karen P ; Lee, Samuel Y. ; Simons, Yael M. ; Yogev, Ram ; Noskin, Gary A. / Indirect protection of adults from rotavirus by pediatric rotavirus vaccination. In: Clinical Infectious Diseases. 2013 ; Vol. 56, No. 6. pp. 755-760.
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title = "Indirect protection of adults from rotavirus by pediatric rotavirus vaccination",
abstract = "Background. Pediatric vaccination has resulted in declines in disease in unvaccinated individuals through decreasing pathogen circulation in the community. About 2 years after implementation of pediatric rotavirus vaccination in the United States, dramatic declines in rotavirus disease were observed in both vaccinated and unvaccinated children. Whether this protection extends to adults is unknown. Methods. The prevalence of rotavirus, as determined by Rotaclone enzyme immunoassay, in adults who had stools submitted for bacterial stool culture (BSC) between February to May to Northwestern Memorial Hospital, Chicago, was compared between the prepediatric impact era (2006-2007) and the pediatric impact era (2008-2010). Isolates were genotyped and clinical characteristics of those with rotavirus were compared. Results. Of the 5788 BSC sent, 4725 met inclusion criteria and 3530 of these (74.7{\%}) were saved for rotavirus testing. The prevalence of rotavirus among adults who had stool sent for BSC declined from 4.35{\%} in 2006-2007 to 2.24{\%} in 2008-2010 (a relative decline of 48.4{\%}; P =. 0007). The decline in the prevalence of rotavirus was of similar significant magnitude in both outpatients and inpatients. Marked year-to-year variability was observed in circulating rotavirus genotypes, with strain G2P[4] accounting for 24{\%}; G1P[8], 22{\%}; G3P[8], 11{\%}; and G12P[6], 10{\%} overall. About 30{\%} of adults from whom rotavirus was isolated were immunocompromised and this remained constant. Conclusions. Pediatric rotavirus vaccination correlated with a relative decline of almost 50{\%} in rotavirus identified from adult BSC during the peak rotavirus season, suggesting that pediatric rotavirus vaccination protects adults from rotavirus.",
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author = "Anderson, {Evan J.} and Shippee, {Deanna B.} and Weinrobe, {Melissa H.} and Bregger, {Melissa Danyella} and Katz, {Ben Z} and Susheel Reddy and Cuyugan, {Mary Gene Karen P} and Lee, {Samuel Y.} and Simons, {Yael M.} and Ram Yogev and Noskin, {Gary A}",
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month = "3",
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Anderson, EJ, Shippee, DB, Weinrobe, MH, Bregger, MD, Katz, BZ, Reddy, S, Cuyugan, MGKP, Lee, SY, Simons, YM, Yogev, R & Noskin, GA 2013, 'Indirect protection of adults from rotavirus by pediatric rotavirus vaccination', Clinical Infectious Diseases, vol. 56, no. 6, pp. 755-760. https://doi.org/10.1093/cid/cis1010

Indirect protection of adults from rotavirus by pediatric rotavirus vaccination. / Anderson, Evan J.; Shippee, Deanna B.; Weinrobe, Melissa H.; Bregger, Melissa Danyella; Katz, Ben Z; Reddy, Susheel; Cuyugan, Mary Gene Karen P; Lee, Samuel Y.; Simons, Yael M.; Yogev, Ram; Noskin, Gary A.

In: Clinical Infectious Diseases, Vol. 56, No. 6, 15.03.2013, p. 755-760.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Indirect protection of adults from rotavirus by pediatric rotavirus vaccination

AU - Anderson, Evan J.

AU - Shippee, Deanna B.

AU - Weinrobe, Melissa H.

AU - Bregger, Melissa Danyella

AU - Katz, Ben Z

AU - Reddy, Susheel

AU - Cuyugan, Mary Gene Karen P

AU - Lee, Samuel Y.

AU - Simons, Yael M.

AU - Yogev, Ram

AU - Noskin, Gary A

PY - 2013/3/15

Y1 - 2013/3/15

N2 - Background. Pediatric vaccination has resulted in declines in disease in unvaccinated individuals through decreasing pathogen circulation in the community. About 2 years after implementation of pediatric rotavirus vaccination in the United States, dramatic declines in rotavirus disease were observed in both vaccinated and unvaccinated children. Whether this protection extends to adults is unknown. Methods. The prevalence of rotavirus, as determined by Rotaclone enzyme immunoassay, in adults who had stools submitted for bacterial stool culture (BSC) between February to May to Northwestern Memorial Hospital, Chicago, was compared between the prepediatric impact era (2006-2007) and the pediatric impact era (2008-2010). Isolates were genotyped and clinical characteristics of those with rotavirus were compared. Results. Of the 5788 BSC sent, 4725 met inclusion criteria and 3530 of these (74.7%) were saved for rotavirus testing. The prevalence of rotavirus among adults who had stool sent for BSC declined from 4.35% in 2006-2007 to 2.24% in 2008-2010 (a relative decline of 48.4%; P =. 0007). The decline in the prevalence of rotavirus was of similar significant magnitude in both outpatients and inpatients. Marked year-to-year variability was observed in circulating rotavirus genotypes, with strain G2P[4] accounting for 24%; G1P[8], 22%; G3P[8], 11%; and G12P[6], 10% overall. About 30% of adults from whom rotavirus was isolated were immunocompromised and this remained constant. Conclusions. Pediatric rotavirus vaccination correlated with a relative decline of almost 50% in rotavirus identified from adult BSC during the peak rotavirus season, suggesting that pediatric rotavirus vaccination protects adults from rotavirus.

AB - Background. Pediatric vaccination has resulted in declines in disease in unvaccinated individuals through decreasing pathogen circulation in the community. About 2 years after implementation of pediatric rotavirus vaccination in the United States, dramatic declines in rotavirus disease were observed in both vaccinated and unvaccinated children. Whether this protection extends to adults is unknown. Methods. The prevalence of rotavirus, as determined by Rotaclone enzyme immunoassay, in adults who had stools submitted for bacterial stool culture (BSC) between February to May to Northwestern Memorial Hospital, Chicago, was compared between the prepediatric impact era (2006-2007) and the pediatric impact era (2008-2010). Isolates were genotyped and clinical characteristics of those with rotavirus were compared. Results. Of the 5788 BSC sent, 4725 met inclusion criteria and 3530 of these (74.7%) were saved for rotavirus testing. The prevalence of rotavirus among adults who had stool sent for BSC declined from 4.35% in 2006-2007 to 2.24% in 2008-2010 (a relative decline of 48.4%; P =. 0007). The decline in the prevalence of rotavirus was of similar significant magnitude in both outpatients and inpatients. Marked year-to-year variability was observed in circulating rotavirus genotypes, with strain G2P[4] accounting for 24%; G1P[8], 22%; G3P[8], 11%; and G12P[6], 10% overall. About 30% of adults from whom rotavirus was isolated were immunocompromised and this remained constant. Conclusions. Pediatric rotavirus vaccination correlated with a relative decline of almost 50% in rotavirus identified from adult BSC during the peak rotavirus season, suggesting that pediatric rotavirus vaccination protects adults from rotavirus.

KW - adult

KW - genotypes

KW - indirect protection

KW - pediatric

KW - rotavirus

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U2 - 10.1093/cid/cis1010

DO - 10.1093/cid/cis1010

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