Individual variability of cerebral autoregulation, posterior cerebral circulation and white matter hyperintensity

Jie Liu, Benjamin Y. Tseng, Muhammad Ayaz Khan, Takashi Tarumi, Candace Hill, Niki Mirshams, Timea M. Hodics, Linda S. Hynan, Rong Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


This study measured the individual variability of static cerebral autoregulation (CA) and determined its associations with brain white matter hyperintensity (WMH) in older adults. Twenty-seven healthy older adults (13 females, 66 ± 6 years) underwent assessment of CA during steady-state changes in mean arterial pressure (MAP) induced by intravenous infusion of sodium nitroprusside (SNP) and phenylephrine. Cerebral blood flow (CBF) was measured using colour-coded duplex ultrasonography at the internal carotid (ICA) and vertebral arteries (VA). CA was quantified by a linear regression slope (CA slope) between percentage changes in cerebrovascular resistance (CVR = MAP/CBF) and MAP relative to baseline values. Periventricular and deep WMH volumes were measured with T2-weighted magnetic resonance imaging. MAP was reduced by -11 ± 7% during SNP, and increased by 21 ± 8% during phenylephrine infusion. CA demonstrated large individual variability with the CA slopes ranging from 0.37 to 2.20 at the ICA and from 0.17 to 3.18 at the VA; no differences in CA were found between the ICA and VA. CA slopes measured at the VA had positive correlations with the total and periventricular WMH volume (r = 0.55 and 0.59, P < 0.01). Collectively, these findings demonstrated the presence of large individual variability of CA in older adults, and that, when measured in the posterior cerebral circulation, it is the higher rather than lower CA reactivity that is associated with WMH severity.

Original languageEnglish (US)
Pages (from-to)3141-3155
Number of pages15
JournalJournal of physiology
Issue number11
StatePublished - Jun 1 2016

ASJC Scopus subject areas

  • Physiology


Dive into the research topics of 'Individual variability of cerebral autoregulation, posterior cerebral circulation and white matter hyperintensity'. Together they form a unique fingerprint.

Cite this