Indomethacin-containing nanoparticles derived from amphiphilic polynorbornene: A model ROMP-based drug encapsulation system

Paul A. Bertin; Keith J. Watson; Son Binh T. Nguyen

doi:10.1021/ma035741+

Indomethacin-containing nanoparticles derived from amphiphilic polynorbornene: A model ROMP-based drug encapsulation system

Paul A. Bertin, Keith J. Watson, Son Binh T. Nguyen^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

A series of monodisperse amphiphilic diblock copolymers containing a high-density of covalently linked indomethacin as the hydrophobic block and pendant hexaethylene glycol monomethyl ether as the hydrophilic block have been synthesized from ring-opening metathesis polymerization (ROMP) using Cl ²(PCy ³) ²Ru=CHPh. Dynamic light scattering (DLS), transmission electron microscopy (TEM), and ¹H NMR spectroscopy have been used to investigate the directed-assembly of these polynorbornene-based copolymers into polymeric nanoparticles in aqueous media as a function of copolymer composition, concentration, and degree of polymerization. The block copolymers formed micelle-like aggregates in the aqueous phase with mean diameters ranging from 993 ± 270 nm to 94 ± 14 nm by TEM. In general, the aggregate size decreased as the overall copolymer length decreased. After incubation in an acidic environment (pH = 3) at 37 °C for 48 h, 20% of the indomethacin was released from the nanoparticles.

Original language	English (US)
Pages (from-to)	8364-8372
Number of pages	9
Journal	Macromolecules
Volume	37
Issue number	22
DOIs	https://doi.org/10.1021/ma035741+
State	Published - Nov 2 2004

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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title = "Indomethacin-containing nanoparticles derived from amphiphilic polynorbornene: A model ROMP-based drug encapsulation system",

abstract = "A series of monodisperse amphiphilic diblock copolymers containing a high-density of covalently linked indomethacin as the hydrophobic block and pendant hexaethylene glycol monomethyl ether as the hydrophilic block have been synthesized from ring-opening metathesis polymerization (ROMP) using Cl 2(PCy 3) 2Ru=CHPh. Dynamic light scattering (DLS), transmission electron microscopy (TEM), and 1H NMR spectroscopy have been used to investigate the directed-assembly of these polynorbornene-based copolymers into polymeric nanoparticles in aqueous media as a function of copolymer composition, concentration, and degree of polymerization. The block copolymers formed micelle-like aggregates in the aqueous phase with mean diameters ranging from 993 ± 270 nm to 94 ± 14 nm by TEM. In general, the aggregate size decreased as the overall copolymer length decreased. After incubation in an acidic environment (pH = 3) at 37 °C for 48 h, 20% of the indomethacin was released from the nanoparticles.",

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AU - Watson, Keith J.

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N2 - A series of monodisperse amphiphilic diblock copolymers containing a high-density of covalently linked indomethacin as the hydrophobic block and pendant hexaethylene glycol monomethyl ether as the hydrophilic block have been synthesized from ring-opening metathesis polymerization (ROMP) using Cl 2(PCy 3) 2Ru=CHPh. Dynamic light scattering (DLS), transmission electron microscopy (TEM), and 1H NMR spectroscopy have been used to investigate the directed-assembly of these polynorbornene-based copolymers into polymeric nanoparticles in aqueous media as a function of copolymer composition, concentration, and degree of polymerization. The block copolymers formed micelle-like aggregates in the aqueous phase with mean diameters ranging from 993 ± 270 nm to 94 ± 14 nm by TEM. In general, the aggregate size decreased as the overall copolymer length decreased. After incubation in an acidic environment (pH = 3) at 37 °C for 48 h, 20% of the indomethacin was released from the nanoparticles.

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Indomethacin-containing nanoparticles derived from amphiphilic polynorbornene: A model ROMP-based drug encapsulation system

Abstract

ASJC Scopus subject areas

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