Indomethacin-containing nanoparticles derived from amphiphilic polynorbornene: A model ROMP-based drug encapsulation system

Paul A. Bertin, Keith J. Watson, SonBinh Nguyen*

*Corresponding author for this work

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

A series of monodisperse amphiphilic diblock copolymers containing a high-density of covalently linked indomethacin as the hydrophobic block and pendant hexaethylene glycol monomethyl ether as the hydrophilic block have been synthesized from ring-opening metathesis polymerization (ROMP) using Cl 2(PCy 3) 2Ru=CHPh. Dynamic light scattering (DLS), transmission electron microscopy (TEM), and 1H NMR spectroscopy have been used to investigate the directed-assembly of these polynorbornene-based copolymers into polymeric nanoparticles in aqueous media as a function of copolymer composition, concentration, and degree of polymerization. The block copolymers formed micelle-like aggregates in the aqueous phase with mean diameters ranging from 993 ± 270 nm to 94 ± 14 nm by TEM. In general, the aggregate size decreased as the overall copolymer length decreased. After incubation in an acidic environment (pH = 3) at 37 °C for 48 h, 20% of the indomethacin was released from the nanoparticles.

Original languageEnglish (US)
Pages (from-to)8364-8372
Number of pages9
JournalMacromolecules
Volume37
Issue number22
DOIs
StatePublished - Nov 2 2004

ASJC Scopus subject areas

  • Materials Chemistry

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