Indomethacin impairs water diuresis in the DI rat: Role of prostaglandins independent of ADH

J. S. Stoff, R. M. Rosa, P. Silva, F. H. Epstein

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The mechanisms by which endogenous renal prostaglandins regulate water excretion were investigated in these studies. Inhibition of prostaglandin synthesis slowed water diuresis in water-loaded unanesthetized Sprague-Dawley rats and in Brattleboro rats with hereditary diabetes insipidus owing to absence of endogenous vasopressin. In both strains, treatment with indomethacin or meclofenamate increased the osmolality of the renal papilla by raising sodium and urea content, and also increased the osmolality of the urine. Endogenous creatinine clearance and solute excretion were unchanged. The data are consistent with an effect of prostaglandins on solute transport by renal tubules and demonstrate that endogenous prostaglandins influence water excretion by a mechanism independent of the pressence of antidiuretic hormone.

Original languageEnglish (US)
Pages (from-to)231-237
Number of pages7
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume10
Issue number3
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Physiology

Fingerprint

Dive into the research topics of 'Indomethacin impairs water diuresis in the DI rat: Role of prostaglandins independent of ADH'. Together they form a unique fingerprint.

Cite this