To the Editor: Dr. Rosa et al. are to be commended for their scientific report and cautious remarks on the treatment of three patients with sickle-cell anemia with induced hyponatremia (November 13 issue).* We have used the same therapy in four patients over the past year, since our early contacts with Dr. Rosa's group. We used the experience and data from the previous year (1979) as a control for the experience with hyponatremia in 1980. Our data confirm that hyponatremia can be induced in the hospital setting and that the use of desmopressin acetate (DDAVP) rather than vasopressin is essential.
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