Induced hypothermia in acute ischemic stroke

Marc A. Lazzaro, Shyam Prabhakaran*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Background: Induced hypothermia is a promising neuroprotective treatment for acute ischemic stroke. Data from both global and focal ischemia animal models have been encouraging. However, only a few small clinical studies have investigated its use in humans. Objective: To review the background, possible mechanisms of action, and the preclinical and clinical data supporting the neuroprotective role of induced hypothermia following acute ischemic stroke. Methods: A literature search was performed using the PubMed database. Only papers in English were reviewed. Results/conclusions: Induced hypothermia is effective as a neuroprotectant in animal models of acute ischemic stroke. Its multimodal mechanism of action makes it a very attractive method of neuroprotection. Although human studies suggest it is safe and feasible, larger randomized controlled trials are necessary to address clinical efficacy and to refine the methods and parameters of induced hypothermia protocols.

Original languageEnglish (US)
Pages (from-to)1161-1174
Number of pages14
JournalExpert Opinion on Investigational Drugs
Volume17
Issue number8
DOIs
StatePublished - Aug 1 2008

Keywords

  • Cardiac arrest
  • Cooling
  • Neuroprotection
  • Penumbra

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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