Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis

Hemant K. Roy; Ramesh K. Wali; Young Kim; Yang Liu; John Hart; Dhananjay P. Kunte; Jennifer L. Koetsier; Michael J. Goldberg; Vadim Backman

doi:10.1016/j.febslet.2007.07.012

Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis

Hemant K. Roy^*, Ramesh K. Wali, Young Kim, Yang Liu, John Hart, Dhananjay P. Kunte, Jennifer L. Koetsier, Michael J. Goldberg, Vadim Backman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We have recently demonstrated that dramatic alteration in mucosal microvascular blood content termed early increase in blood supply (EIBS) is a hallmark of early colon carcinogenesis. In the current study, we elucidate the mechanism of EIBS by assessing iNOS/nitric oxide axis in the histologically normal colonic mucosa of rats treated with the colon-specific carcinogen, azoxymethane. We demonstrate that there was a strong temporal correlation between EIBS and iNOS expression/activity. Importantly, we also observed that short-term treatment with nitric oxide inhibitor abrogated EIBS. These data indicate that iNOS induction may have a critical role in augmenting the predysplastic mucosal blood supply and thereby fostering colon carcinogenesis.

Original language	English (US)
Pages (from-to)	3857-3862
Number of pages	6
Journal	FEBS Letters
Volume	581
Issue number	20
DOIs	https://doi.org/10.1016/j.febslet.2007.07.012
State	Published - Aug 7 2007

Keywords

Colon cancer
Microvasculature
Nitric oxide
iNOS

ASJC Scopus subject areas

Genetics
Molecular Biology
Biophysics
Structural Biology
Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.febslet.2007.07.012

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@article{b0b90ba1baef47beb6d6cd79a0213954,

title = "Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis",

abstract = "We have recently demonstrated that dramatic alteration in mucosal microvascular blood content termed early increase in blood supply (EIBS) is a hallmark of early colon carcinogenesis. In the current study, we elucidate the mechanism of EIBS by assessing iNOS/nitric oxide axis in the histologically normal colonic mucosa of rats treated with the colon-specific carcinogen, azoxymethane. We demonstrate that there was a strong temporal correlation between EIBS and iNOS expression/activity. Importantly, we also observed that short-term treatment with nitric oxide inhibitor abrogated EIBS. These data indicate that iNOS induction may have a critical role in augmenting the predysplastic mucosal blood supply and thereby fostering colon carcinogenesis.",

keywords = "Colon cancer, Microvasculature, Nitric oxide, iNOS",

author = "Roy, {Hemant K.} and Wali, {Ramesh K.} and Young Kim and Yang Liu and John Hart and Kunte, {Dhananjay P.} and Koetsier, {Jennifer L.} and Goldberg, {Michael J.} and Vadim Backman",

note = "Funding Information: Supported by grants from the National Cancer Institute R01CA109861, R03CA119261, U01CA111257 (Early Detection Research Network).",

year = "2007",

month = aug,

day = "7",

doi = "10.1016/j.febslet.2007.07.012",

language = "English (US)",

volume = "581",

pages = "3857--3862",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

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TY - JOUR

T1 - Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis

AU - Roy, Hemant K.

AU - Wali, Ramesh K.

AU - Kim, Young

AU - Liu, Yang

AU - Hart, John

AU - Kunte, Dhananjay P.

AU - Koetsier, Jennifer L.

AU - Goldberg, Michael J.

AU - Backman, Vadim

N1 - Funding Information: Supported by grants from the National Cancer Institute R01CA109861, R03CA119261, U01CA111257 (Early Detection Research Network).

PY - 2007/8/7

Y1 - 2007/8/7

N2 - We have recently demonstrated that dramatic alteration in mucosal microvascular blood content termed early increase in blood supply (EIBS) is a hallmark of early colon carcinogenesis. In the current study, we elucidate the mechanism of EIBS by assessing iNOS/nitric oxide axis in the histologically normal colonic mucosa of rats treated with the colon-specific carcinogen, azoxymethane. We demonstrate that there was a strong temporal correlation between EIBS and iNOS expression/activity. Importantly, we also observed that short-term treatment with nitric oxide inhibitor abrogated EIBS. These data indicate that iNOS induction may have a critical role in augmenting the predysplastic mucosal blood supply and thereby fostering colon carcinogenesis.

AB - We have recently demonstrated that dramatic alteration in mucosal microvascular blood content termed early increase in blood supply (EIBS) is a hallmark of early colon carcinogenesis. In the current study, we elucidate the mechanism of EIBS by assessing iNOS/nitric oxide axis in the histologically normal colonic mucosa of rats treated with the colon-specific carcinogen, azoxymethane. We demonstrate that there was a strong temporal correlation between EIBS and iNOS expression/activity. Importantly, we also observed that short-term treatment with nitric oxide inhibitor abrogated EIBS. These data indicate that iNOS induction may have a critical role in augmenting the predysplastic mucosal blood supply and thereby fostering colon carcinogenesis.

KW - Colon cancer

KW - Microvasculature

KW - Nitric oxide

KW - iNOS

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U2 - 10.1016/j.febslet.2007.07.012

DO - 10.1016/j.febslet.2007.07.012

M3 - Article

C2 - 17658518

AN - SCOPUS:34548614576

SN - 0014-5793

VL - 581

SP - 3857

EP - 3862

JO - FEBS Letters

JF - FEBS Letters

IS - 20

ER -

Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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