Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis

Hemant K. Roy*, Ramesh K. Wali, Young Kim, Yang Liu, John Hart, Dhananjay P. Kunte, Jennifer L. Koetsier, Michael J. Goldberg, Vadim Backman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

We have recently demonstrated that dramatic alteration in mucosal microvascular blood content termed early increase in blood supply (EIBS) is a hallmark of early colon carcinogenesis. In the current study, we elucidate the mechanism of EIBS by assessing iNOS/nitric oxide axis in the histologically normal colonic mucosa of rats treated with the colon-specific carcinogen, azoxymethane. We demonstrate that there was a strong temporal correlation between EIBS and iNOS expression/activity. Importantly, we also observed that short-term treatment with nitric oxide inhibitor abrogated EIBS. These data indicate that iNOS induction may have a critical role in augmenting the predysplastic mucosal blood supply and thereby fostering colon carcinogenesis.

Original languageEnglish (US)
Pages (from-to)3857-3862
Number of pages6
JournalFEBS Letters
Volume581
Issue number20
DOIs
StatePublished - Aug 7 2007

Keywords

  • Colon cancer
  • Microvasculature
  • Nitric oxide
  • iNOS

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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