Induction and patterning of the neural crest, a stem cell-like precursor population

Carole LaBonne*, Marianne Bronner-Fraser

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations


The neural crest is a multipotent precursor population which ulimately generates much of the peripheral nervous system, epidermal pigment cells, and a variety of mesectodermal derivatives. Individual multipotent neural crest cells are capable of some self-renewing divisions, and based upon this criteria can be considered stem cells. Considerable progress has been made in recent years toward understanding how this important population of progenitor cells is initially established in the early embryo, and how cell-intrinsic and non-cell-instristic factors mediate their subsequent lineage segregation and differentiation.

Original languageEnglish (US)
Pages (from-to)175-189
Number of pages15
JournalJournal of Neurobiology
Issue number2
StatePublished - Aug 17 1998


  • Avian
  • Lineage determination
  • Neural crest
  • Stem cells
  • Xenopus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience


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