TY - JOUR
T1 - Induction and reinduction of experimental allergic encephalomyelitis in DA rats
T2 - The effect of age and encephalitogen
AU - Mirjana, Dimitrijević
AU - Olgica, Laban
AU - Stanislava, Stanojević
AU - Jelena, Radulović
PY - 2000
Y1 - 2000
N2 - Susceptibility to experimental allergic encephalomyelitis (EAE) was investigated in DA rats of both sexes, aged 5, 8 or 27 weeks. Guinea pig or Lewis rat spinal cords (GPSC or RSC) emulsified in complete Freund's adjuvant were used for both induction and reinduction of EAE. The results showed that: a) sex has no influence on clinical signs of EAE in young DA rats aged 5 or 8 weeks; b) susceptibility to EAE induction increases with age; c) RSC is a more potent encephalitogen than GPSC; d) GPSC is a more effective antigen for anti-MBP antibody production than RSC; e) anti-MBP antibody levels are not correlated with clinical score of EAE; f) EAE can be reinduced in 27-week- old rats if RSC is used for induction and/or reinduction; and g) anti-MBP antibodies are not related to resistance to EAE reinduction in DA rats.
AB - Susceptibility to experimental allergic encephalomyelitis (EAE) was investigated in DA rats of both sexes, aged 5, 8 or 27 weeks. Guinea pig or Lewis rat spinal cords (GPSC or RSC) emulsified in complete Freund's adjuvant were used for both induction and reinduction of EAE. The results showed that: a) sex has no influence on clinical signs of EAE in young DA rats aged 5 or 8 weeks; b) susceptibility to EAE induction increases with age; c) RSC is a more potent encephalitogen than GPSC; d) GPSC is a more effective antigen for anti-MBP antibody production than RSC; e) anti-MBP antibody levels are not correlated with clinical score of EAE; f) EAE can be reinduced in 27-week- old rats if RSC is used for induction and/or reinduction; and g) anti-MBP antibodies are not related to resistance to EAE reinduction in DA rats.
KW - Anti-myelin basic protein antibodies
KW - DA rats
KW - Experimental allergic encephalomyelitis
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M3 - Article
AN - SCOPUS:0346355832
VL - 50
SP - 289
EP - 296
JO - Acta Veterinaria
JF - Acta Veterinaria
SN - 0567-8315
IS - 5-6
ER -