Abstract
Umbilical cord blood (UCB) has become a frequent source of allogeneic hematopoietic stem cells for transplantation. Of theoretical concern is a potential decrease in the graft vs. leukemia (GvL) effect, given the lesser degree of graft vs. host disease (GvHD) with this donor source. We report a case of recurrent acute non-lymphoblastic leukemia (ANLL) following stem cell transplantation with unrelated mismatched UCB, which responded to the induction of GvHD. The response was documented both morphologically and by evaluation of chimeric engraftment by molecular DNA techniques. In addition, WT-1, a purported marker of minimal residual disease in acute leukemia, correlated with remission status in this patient. In summary, the GvL effect is seen with allogeneic UCB transplantation and has the potential to be induced along with GvHD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 348-351 |
| Number of pages | 4 |
| Journal | Pediatric Transplantation |
| Volume | 6 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1 2002 |
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Keywords
- Cord blood
- Graft versus leukemia
- GvHD
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Transplantation
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Induction of a transient graft vs. leukemia effect following unrelated cord blood transplantation. / Haut, Paul R.; Gonzalez-Ryan, Lydia; Wang, Ling Jia; Olszewski, Marie; Morgan, Elaine R; Kletzel, Morris.
In: Pediatric Transplantation, Vol. 6, No. 4, 01.08.2002, p. 348-351.Research output: Contribution to journal › Article
TY - JOUR
T1 - Induction of a transient graft vs. leukemia effect following unrelated cord blood transplantation
AU - Haut, Paul R.
AU - Gonzalez-Ryan, Lydia
AU - Wang, Ling Jia
AU - Olszewski, Marie
AU - Morgan, Elaine R
AU - Kletzel, Morris
PY - 2002/8/1
Y1 - 2002/8/1
N2 - Umbilical cord blood (UCB) has become a frequent source of allogeneic hematopoietic stem cells for transplantation. Of theoretical concern is a potential decrease in the graft vs. leukemia (GvL) effect, given the lesser degree of graft vs. host disease (GvHD) with this donor source. We report a case of recurrent acute non-lymphoblastic leukemia (ANLL) following stem cell transplantation with unrelated mismatched UCB, which responded to the induction of GvHD. The response was documented both morphologically and by evaluation of chimeric engraftment by molecular DNA techniques. In addition, WT-1, a purported marker of minimal residual disease in acute leukemia, correlated with remission status in this patient. In summary, the GvL effect is seen with allogeneic UCB transplantation and has the potential to be induced along with GvHD.
AB - Umbilical cord blood (UCB) has become a frequent source of allogeneic hematopoietic stem cells for transplantation. Of theoretical concern is a potential decrease in the graft vs. leukemia (GvL) effect, given the lesser degree of graft vs. host disease (GvHD) with this donor source. We report a case of recurrent acute non-lymphoblastic leukemia (ANLL) following stem cell transplantation with unrelated mismatched UCB, which responded to the induction of GvHD. The response was documented both morphologically and by evaluation of chimeric engraftment by molecular DNA techniques. In addition, WT-1, a purported marker of minimal residual disease in acute leukemia, correlated with remission status in this patient. In summary, the GvL effect is seen with allogeneic UCB transplantation and has the potential to be induced along with GvHD.
KW - Cord blood
KW - Graft versus leukemia
KW - GvHD
UR - http://www.scopus.com/inward/record.url?scp=0036670998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036670998&partnerID=8YFLogxK
U2 - 10.1034/j.1399-3046.2002.00215.x
DO - 10.1034/j.1399-3046.2002.00215.x
M3 - Article
VL - 6
SP - 348
EP - 351
JO - Pediatric Transplantation
JF - Pediatric Transplantation
SN - 1397-3142
IS - 4
ER -