Induction of a transient graft vs. leukemia effect following unrelated cord blood transplantation

Paul R. Haut*, Lydia Gonzalez-Ryan, Ling Jia Wang, Marie Olszewski, Elaine R Morgan, Morris Kletzel

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Umbilical cord blood (UCB) has become a frequent source of allogeneic hematopoietic stem cells for transplantation. Of theoretical concern is a potential decrease in the graft vs. leukemia (GvL) effect, given the lesser degree of graft vs. host disease (GvHD) with this donor source. We report a case of recurrent acute non-lymphoblastic leukemia (ANLL) following stem cell transplantation with unrelated mismatched UCB, which responded to the induction of GvHD. The response was documented both morphologically and by evaluation of chimeric engraftment by molecular DNA techniques. In addition, WT-1, a purported marker of minimal residual disease in acute leukemia, correlated with remission status in this patient. In summary, the GvL effect is seen with allogeneic UCB transplantation and has the potential to be induced along with GvHD.

Original languageEnglish (US)
Pages (from-to)348-351
Number of pages4
JournalPediatric Transplantation
Volume6
Issue number4
DOIs
StatePublished - Aug 1 2002

Fingerprint

Fetal Blood
Leukemia
Transplantation
Transplants
Hematopoietic Stem Cell Transplantation
Residual Neoplasm
Stem Cell Transplantation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Tissue Donors
DNA

Keywords

  • Cord blood
  • Graft versus leukemia
  • GvHD

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Haut, Paul R. ; Gonzalez-Ryan, Lydia ; Wang, Ling Jia ; Olszewski, Marie ; Morgan, Elaine R ; Kletzel, Morris. / Induction of a transient graft vs. leukemia effect following unrelated cord blood transplantation. In: Pediatric Transplantation. 2002 ; Vol. 6, No. 4. pp. 348-351.
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Induction of a transient graft vs. leukemia effect following unrelated cord blood transplantation. / Haut, Paul R.; Gonzalez-Ryan, Lydia; Wang, Ling Jia; Olszewski, Marie; Morgan, Elaine R; Kletzel, Morris.

In: Pediatric Transplantation, Vol. 6, No. 4, 01.08.2002, p. 348-351.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Induction of a transient graft vs. leukemia effect following unrelated cord blood transplantation

AU - Haut, Paul R.

AU - Gonzalez-Ryan, Lydia

AU - Wang, Ling Jia

AU - Olszewski, Marie

AU - Morgan, Elaine R

AU - Kletzel, Morris

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AB - Umbilical cord blood (UCB) has become a frequent source of allogeneic hematopoietic stem cells for transplantation. Of theoretical concern is a potential decrease in the graft vs. leukemia (GvL) effect, given the lesser degree of graft vs. host disease (GvHD) with this donor source. We report a case of recurrent acute non-lymphoblastic leukemia (ANLL) following stem cell transplantation with unrelated mismatched UCB, which responded to the induction of GvHD. The response was documented both morphologically and by evaluation of chimeric engraftment by molecular DNA techniques. In addition, WT-1, a purported marker of minimal residual disease in acute leukemia, correlated with remission status in this patient. In summary, the GvL effect is seen with allogeneic UCB transplantation and has the potential to be induced along with GvHD.

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