Induction of a transient graft vs. leukemia effect following unrelated cord blood transplantation

Paul R. Haut; Lydia Gonzalez-Ryan; Ling Jia Wang; Marie Olszewski; Elaine Morgan; Morris Kletzel

doi:10.1034/j.1399-3046.2002.00215.x

Induction of a transient graft vs. leukemia effect following unrelated cord blood transplantation

Paul R. Haut^*, Lydia Gonzalez-Ryan, Ling Jia Wang, Marie Olszewski, Elaine Morgan, Morris Kletzel

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Umbilical cord blood (UCB) has become a frequent source of allogeneic hematopoietic stem cells for transplantation. Of theoretical concern is a potential decrease in the graft vs. leukemia (GvL) effect, given the lesser degree of graft vs. host disease (GvHD) with this donor source. We report a case of recurrent acute non-lymphoblastic leukemia (ANLL) following stem cell transplantation with unrelated mismatched UCB, which responded to the induction of GvHD. The response was documented both morphologically and by evaluation of chimeric engraftment by molecular DNA techniques. In addition, WT-1, a purported marker of minimal residual disease in acute leukemia, correlated with remission status in this patient. In summary, the GvL effect is seen with allogeneic UCB transplantation and has the potential to be induced along with GvHD.

Original language	English (US)
Pages (from-to)	348-351
Number of pages	4
Journal	Pediatric transplantation
Volume	6
Issue number	4
DOIs	https://doi.org/10.1034/j.1399-3046.2002.00215.x
State	Published - Aug 2002

Keywords

Cord blood
Graft versus leukemia
GvHD

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Transplantation

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10.1034/j.1399-3046.2002.00215.x

Cite this

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title = "Induction of a transient graft vs. leukemia effect following unrelated cord blood transplantation",

abstract = "Umbilical cord blood (UCB) has become a frequent source of allogeneic hematopoietic stem cells for transplantation. Of theoretical concern is a potential decrease in the graft vs. leukemia (GvL) effect, given the lesser degree of graft vs. host disease (GvHD) with this donor source. We report a case of recurrent acute non-lymphoblastic leukemia (ANLL) following stem cell transplantation with unrelated mismatched UCB, which responded to the induction of GvHD. The response was documented both morphologically and by evaluation of chimeric engraftment by molecular DNA techniques. In addition, WT-1, a purported marker of minimal residual disease in acute leukemia, correlated with remission status in this patient. In summary, the GvL effect is seen with allogeneic UCB transplantation and has the potential to be induced along with GvHD.",

keywords = "Cord blood, Graft versus leukemia, GvHD",

author = "Haut, {Paul R.} and Lydia Gonzalez-Ryan and Wang, {Ling Jia} and Marie Olszewski and Elaine Morgan and Morris Kletzel",

year = "2002",

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doi = "10.1034/j.1399-3046.2002.00215.x",

language = "English (US)",

volume = "6",

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T1 - Induction of a transient graft vs. leukemia effect following unrelated cord blood transplantation

AU - Haut, Paul R.

AU - Gonzalez-Ryan, Lydia

AU - Wang, Ling Jia

AU - Olszewski, Marie

AU - Morgan, Elaine

AU - Kletzel, Morris

PY - 2002/8

Y1 - 2002/8

N2 - Umbilical cord blood (UCB) has become a frequent source of allogeneic hematopoietic stem cells for transplantation. Of theoretical concern is a potential decrease in the graft vs. leukemia (GvL) effect, given the lesser degree of graft vs. host disease (GvHD) with this donor source. We report a case of recurrent acute non-lymphoblastic leukemia (ANLL) following stem cell transplantation with unrelated mismatched UCB, which responded to the induction of GvHD. The response was documented both morphologically and by evaluation of chimeric engraftment by molecular DNA techniques. In addition, WT-1, a purported marker of minimal residual disease in acute leukemia, correlated with remission status in this patient. In summary, the GvL effect is seen with allogeneic UCB transplantation and has the potential to be induced along with GvHD.

AB - Umbilical cord blood (UCB) has become a frequent source of allogeneic hematopoietic stem cells for transplantation. Of theoretical concern is a potential decrease in the graft vs. leukemia (GvL) effect, given the lesser degree of graft vs. host disease (GvHD) with this donor source. We report a case of recurrent acute non-lymphoblastic leukemia (ANLL) following stem cell transplantation with unrelated mismatched UCB, which responded to the induction of GvHD. The response was documented both morphologically and by evaluation of chimeric engraftment by molecular DNA techniques. In addition, WT-1, a purported marker of minimal residual disease in acute leukemia, correlated with remission status in this patient. In summary, the GvL effect is seen with allogeneic UCB transplantation and has the potential to be induced along with GvHD.

KW - Cord blood

KW - Graft versus leukemia

KW - GvHD

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Induction of a transient graft vs. leukemia effect following unrelated cord blood transplantation

Abstract

Keywords

ASJC Scopus subject areas

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