@inbook{91086f70cebc4db8ba0703147d74a6bb,
title = "Induction of allergic rhinitis in mice",
abstract = "We describe a method for allergic rhinitis (AR) induction in mice. Methodology involves nasal infusions of small volumes of ovalbumin for both initial sensitization and challenges. The latter are frequent and carried out over several weeks. This methodology more closely resembles natural AR induction than does the common use of systemic sensitization, often with adjuvants, followed by nasal challenges with relatively large allergen volumes. Also described are methodologies for collection of cardiac blood and perfusion for preparation of histological samples, both essential in verifying AR induction in individual animals.",
keywords = "Allergic rhinitis induction, Cardiac blood collection, Eosinophils, Mouse perfusion, Murine allergic rhinitis model, Nasal sinuses, Nasal tissues, Olfactory epithelium, Ovalbumin, Respiratory epithelium",
author = "Carr, {Virginia Mc Millan} and Alan Robinson",
year = "2013",
month = jan,
day = "1",
doi = "10.1007/978-1-62703-496-8_12",
language = "English (US)",
isbn = "9781627034951",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc",
pages = "145--158",
booktitle = "Mouse Models of Allergic Disease",
}