Induction of allograft tolerance in rats by an HLA class-I-derived peptide and cyclosporine A

S. Nisco, P. Vriens, G. Hoyt, S. C. Lyu, F. Farfan, P. Pouletty, A. M. Krensky, C. Clayberger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

T cell recognition of MHC molecules initiates a cascade of events resulting in allograft rejection. CTLs damage the graft by targeting nonself-MHC class I molecules. We and others have previously shown that small synthetic peptides corresponding to regions of certain MHC class I molecules can inhibit the CTL response against MHC class I alloantigens in vitro. Here we report that rat heart allografts survived indefinitely when transplanted into recipients treated with a synthetic peptide corresponding to residues 75-84 of the human HLA-B7 molecule (B7.75-84) in combination with a subtherapeutic dose of cyclosporine A. Furthermore, this treatment induced long-term donor-specific tolerance that was mediated by anergic cells, indicating that such peptides may have potential as therapeutics for human organ transplantation.

Original languageEnglish (US)
Pages (from-to)3786-3792
Number of pages7
JournalJournal of Immunology
Volume152
Issue number8
StatePublished - Apr 15 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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