Induction of hepatocytes in the pancreas of copper-depleted rats following copper repletion

M. S. Rao; V. Subbarao; J. K. Reddy

doi:10.1016/0045-6039(86)90005-9

Induction of hepatocytes in the pancreas of copper-depleted rats following copper repletion

M. S. Rao^*, V. Subbarao, J. K. Reddy

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

Pancreatic hepatocytes are induced in rats maintained on copper-deficient diet containing 0.6% d-penicillamine for 8-10 weeks, followed by copper repletion. These induced hepatocytes are morphologically and functionally very similar to parenchymal cells of the liver. Immunofluorescence stains demonstrated the presence of albumin and catalase in these cells. Strains for pancreatic enzymes and hormones were negative. As expected, the hypolipidemic compounds, ciprofibrate, induced peroxisome proliferation in these cells. These results indicate that a simple depletion and repletion of copper can trigger transdifferentiation in the pancreas of adult rats.

Original language	English (US)
Pages (from-to)	109-117
Number of pages	9
Journal	Cell Differentiation
Volume	18
Issue number	2
DOIs	https://doi.org/10.1016/0045-6039(86)90005-9
State	Published - Mar 1986

Funding

We thank J.D. Prasad for excellent technical assistance. This work was supported by NIH grants CA 36043 and GM 23750.

Keywords

albumin
copper deficiency
islets
pancreatic hepatocytes
peroxisomes
transdifferentiation

ASJC Scopus subject areas

Developmental Biology

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10.1016/0045-6039(86)90005-9

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title = "Induction of hepatocytes in the pancreas of copper-depleted rats following copper repletion",

abstract = "Pancreatic hepatocytes are induced in rats maintained on copper-deficient diet containing 0.6% d-penicillamine for 8-10 weeks, followed by copper repletion. These induced hepatocytes are morphologically and functionally very similar to parenchymal cells of the liver. Immunofluorescence stains demonstrated the presence of albumin and catalase in these cells. Strains for pancreatic enzymes and hormones were negative. As expected, the hypolipidemic compounds, ciprofibrate, induced peroxisome proliferation in these cells. These results indicate that a simple depletion and repletion of copper can trigger transdifferentiation in the pancreas of adult rats.",

keywords = "albumin, copper deficiency, islets, pancreatic hepatocytes, peroxisomes, transdifferentiation",

author = "Rao, {M. S.} and V. Subbarao and Reddy, {J. K.}",

note = "Funding Information: We thank J.D. Prasad for excellent technical assistance. This work was supported by NIH grants CA 36043 and GM 23750.",

year = "1986",

month = mar,

doi = "10.1016/0045-6039(86)90005-9",

language = "English (US)",

volume = "18",

pages = "109--117",

journal = "Cell Differentiation",

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TY - JOUR

T1 - Induction of hepatocytes in the pancreas of copper-depleted rats following copper repletion

AU - Rao, M. S.

AU - Subbarao, V.

AU - Reddy, J. K.

N1 - Funding Information: We thank J.D. Prasad for excellent technical assistance. This work was supported by NIH grants CA 36043 and GM 23750.

PY - 1986/3

Y1 - 1986/3

N2 - Pancreatic hepatocytes are induced in rats maintained on copper-deficient diet containing 0.6% d-penicillamine for 8-10 weeks, followed by copper repletion. These induced hepatocytes are morphologically and functionally very similar to parenchymal cells of the liver. Immunofluorescence stains demonstrated the presence of albumin and catalase in these cells. Strains for pancreatic enzymes and hormones were negative. As expected, the hypolipidemic compounds, ciprofibrate, induced peroxisome proliferation in these cells. These results indicate that a simple depletion and repletion of copper can trigger transdifferentiation in the pancreas of adult rats.

AB - Pancreatic hepatocytes are induced in rats maintained on copper-deficient diet containing 0.6% d-penicillamine for 8-10 weeks, followed by copper repletion. These induced hepatocytes are morphologically and functionally very similar to parenchymal cells of the liver. Immunofluorescence stains demonstrated the presence of albumin and catalase in these cells. Strains for pancreatic enzymes and hormones were negative. As expected, the hypolipidemic compounds, ciprofibrate, induced peroxisome proliferation in these cells. These results indicate that a simple depletion and repletion of copper can trigger transdifferentiation in the pancreas of adult rats.

KW - albumin

KW - copper deficiency

KW - islets

KW - pancreatic hepatocytes

KW - peroxisomes

KW - transdifferentiation

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SN - 0045-6039

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JO - Cell Differentiation

JF - Cell Differentiation

IS - 2

ER -

Induction of hepatocytes in the pancreas of copper-depleted rats following copper repletion

Abstract

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Keywords

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