Induction of immunodeficiency in mice by injection with syngeneic splenocytes immune to semi-allogeneic hybrid cells

Byung S. Kim*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Intravenous transfer of BALB/c spleen cells (1-10 × 106) immunized against semi-allogeneic hybrid cells bearing H-2k antigens into BALB/c mice resulted in splenomegaly (2- to 6-fold). As few as 2 × 104 spleen cells could transfer splenomegaly. A significant spleen enlargement was seen from 2 weeks after cell transfer and reached the peak level at 3 weeks. Those mice with splenomegaly displayed markedly reduced levels of proliferative responses to concanavalin A and lipopolysaccharide. However, the levels of the major Ig classes (i.e., IgG, IgM, and IgA) in the immunodeficient mice were significantly elevated. Such induction of immunodeficiency in mice may help further to understand the acquired immunodeficiency syndrome of humans.

Original languageEnglish (US)
Pages (from-to)222-227
Number of pages6
JournalCellular Immunology
Volume88
Issue number1
DOIs
StatePublished - Oct 1 1984

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Induction of immunodeficiency in mice by injection with syngeneic splenocytes immune to semi-allogeneic hybrid cells'. Together they form a unique fingerprint.

  • Cite this