Induction of labor compared to dilation and evacuation for postmortem analysis

A. K. Lal*, M. A. Kominiarek, N. M. Sprawka

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: This study aimed to evaluate the ability to obtain autopsy and cytogenetics after midtrimester termination. Methods: A retrospective cohort study of women undergoing termination, via induction or dilation and evacuation (D&E), at 16 0/7-23 6/7weeks was performed. Exclusion criteria were elective termination, preterm labor, PPROM, and no autopsy or cytogenetic exam performed. The ability to obtain cytogenetics and autopsy as well as complications rates were compared between the two groups with Chi-square tests. Results: Of the 469 women who met the inclusion criteria, 158 had an induction and 312 had a D&E. The induction of labor group had higher mean gestational ages, p<0.01. Successful autopsy was more likely in the induction group, 94.3%, versus D&E group, 34.7%, p=0.01. There was no difference in ability to obtain cytogenetics between the two groups, 89.1% in the induction group, and 92.3% in D&E group, p=0.4. There was a difference in the total complication rates between the groups, 9.8% (26) in the induction versus 6.4% (20) in the D&E group, p<0.01; however, there was no difference in major complications. Conclusions: Midtrimester terminations by induction were more likely to have successful autopsies when compared with D&E. The ability to obtain cytogenetics was similar regardless of termination mode.

Original languageEnglish (US)
Pages (from-to)547-551
Number of pages5
JournalPrenatal Diagnosis
Volume34
Issue number6
DOIs
StatePublished - Jan 1 2014

Fingerprint

Induced Labor
Cytogenetics
Dilatation
Autopsy
Second Pregnancy Trimester
Premature Obstetric Labor
Chi-Square Distribution
Gestational Age
Cohort Studies
Retrospective Studies

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)

Cite this

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title = "Induction of labor compared to dilation and evacuation for postmortem analysis",
abstract = "Objective: This study aimed to evaluate the ability to obtain autopsy and cytogenetics after midtrimester termination. Methods: A retrospective cohort study of women undergoing termination, via induction or dilation and evacuation (D&E), at 16 0/7-23 6/7weeks was performed. Exclusion criteria were elective termination, preterm labor, PPROM, and no autopsy or cytogenetic exam performed. The ability to obtain cytogenetics and autopsy as well as complications rates were compared between the two groups with Chi-square tests. Results: Of the 469 women who met the inclusion criteria, 158 had an induction and 312 had a D&E. The induction of labor group had higher mean gestational ages, p<0.01. Successful autopsy was more likely in the induction group, 94.3{\%}, versus D&E group, 34.7{\%}, p=0.01. There was no difference in ability to obtain cytogenetics between the two groups, 89.1{\%} in the induction group, and 92.3{\%} in D&E group, p=0.4. There was a difference in the total complication rates between the groups, 9.8{\%} (26) in the induction versus 6.4{\%} (20) in the D&E group, p<0.01; however, there was no difference in major complications. Conclusions: Midtrimester terminations by induction were more likely to have successful autopsies when compared with D&E. The ability to obtain cytogenetics was similar regardless of termination mode.",
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Induction of labor compared to dilation and evacuation for postmortem analysis. / Lal, A. K.; Kominiarek, M. A.; Sprawka, N. M.

In: Prenatal Diagnosis, Vol. 34, No. 6, 01.01.2014, p. 547-551.

Research output: Contribution to journalArticle

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AB - Objective: This study aimed to evaluate the ability to obtain autopsy and cytogenetics after midtrimester termination. Methods: A retrospective cohort study of women undergoing termination, via induction or dilation and evacuation (D&E), at 16 0/7-23 6/7weeks was performed. Exclusion criteria were elective termination, preterm labor, PPROM, and no autopsy or cytogenetic exam performed. The ability to obtain cytogenetics and autopsy as well as complications rates were compared between the two groups with Chi-square tests. Results: Of the 469 women who met the inclusion criteria, 158 had an induction and 312 had a D&E. The induction of labor group had higher mean gestational ages, p<0.01. Successful autopsy was more likely in the induction group, 94.3%, versus D&E group, 34.7%, p=0.01. There was no difference in ability to obtain cytogenetics between the two groups, 89.1% in the induction group, and 92.3% in D&E group, p=0.4. There was a difference in the total complication rates between the groups, 9.8% (26) in the induction versus 6.4% (20) in the D&E group, p<0.01; however, there was no difference in major complications. Conclusions: Midtrimester terminations by induction were more likely to have successful autopsies when compared with D&E. The ability to obtain cytogenetics was similar regardless of termination mode.

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