The development of liver tumors was studied in infected and uninfected Fisher 344 rats treated with 3'-methyl-dimethylaminoazobenzene (3'-Me-DAB). Compared with uninfected rats, those chronically infected with Toxoplasma or Besnoitia showed a delay in tumor development after 8, 14 and 19 weeks of carcinogen treatment. However, after another 15 weeks on a regular diet, hepatocellular carcinomas were present in close to 100% and cholangiocarcinomas in about 30% of rats in each group. It is concluded that the induction of liver neoplasms in rats with 3'-Me-DAB is delayed but not prevented in animals chronically infected with Toxoplasma or Besnoitia. The possible role of activated macrophages in mediating this protection is discussed.
|Original language||English (US)|
|Number of pages||8|
|Journal||RES Journal of the Reticuloendothelial Society|
|State||Published - Jan 1 1977|
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