Induction of liver tumors by 3' methyl dimethylaminoazobenzene (3' Me DAB) in rats chronically infected with toxoplasma or besnoitia

J. K. Frenkel, J. K. Reddy

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Abstract

The development of liver tumors was studied in infected and uninfected Fisher 344 rats treated with 3'-methyl-dimethylaminoazobenzene (3'-Me-DAB). Compared with uninfected rats, those chronically infected with Toxoplasma or Besnoitia showed a delay in tumor development after 8, 14 and 19 weeks of carcinogen treatment. However, after another 15 weeks on a regular diet, hepatocellular carcinomas were present in close to 100% and cholangiocarcinomas in about 30% of rats in each group. It is concluded that the induction of liver neoplasms in rats with 3'-Me-DAB is delayed but not prevented in animals chronically infected with Toxoplasma or Besnoitia. The possible role of activated macrophages in mediating this protection is discussed.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalRES Journal of the Reticuloendothelial Society
Volume21
Issue number1
Publication statusPublished - Jan 1 1977

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ASJC Scopus subject areas

  • Hematology

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