TY - JOUR
T1 - Induction of malignant vascular tumors of the liver in guinea pigs treated with 2,2' dihydroxy di n propylnitrosamine
AU - Rao, M. S.
AU - Reddy, J. K.
PY - 1977/1/1
Y1 - 1977/1/1
N2 - The effect of chronic administration of 2,2' dihydroxy di n propylnitrosamine (DHPN) was studied in randombred guinea pigs. DHPN, dissolved in olive oil, was injected sc into 40 animals at a dose of 250 mg/kg body weight/week for 30 weeks, and the animals were observed until their death or termination of the experiment at the end of 40 weeks. Of the 32 guinea pigs that survived more than 20 weeks of DHPN treatment, 23 developed a hemangiosarcoma angiosarcoma of the liver between 22 and 40 weeks. Metastases to lungs, spleen, and peripancreatic lymph nodes were observed in 8 animals. Other tumors included hepatocellular carcinoma (1 animal), cholangiocarcinoma (1 animal), chronic myeloid leukemia (1 animal), acinar cell adenoma of pancreas (1 animal), and acinar cell carcinoma of pancreas (1 animal). In addition, megalocytic change of hepatic cells with intranuclear inclusions, peliosis hepatis, and cholangiomatous lesions were also encountered frequently in te livers.
AB - The effect of chronic administration of 2,2' dihydroxy di n propylnitrosamine (DHPN) was studied in randombred guinea pigs. DHPN, dissolved in olive oil, was injected sc into 40 animals at a dose of 250 mg/kg body weight/week for 30 weeks, and the animals were observed until their death or termination of the experiment at the end of 40 weeks. Of the 32 guinea pigs that survived more than 20 weeks of DHPN treatment, 23 developed a hemangiosarcoma angiosarcoma of the liver between 22 and 40 weeks. Metastases to lungs, spleen, and peripancreatic lymph nodes were observed in 8 animals. Other tumors included hepatocellular carcinoma (1 animal), cholangiocarcinoma (1 animal), chronic myeloid leukemia (1 animal), acinar cell adenoma of pancreas (1 animal), and acinar cell carcinoma of pancreas (1 animal). In addition, megalocytic change of hepatic cells with intranuclear inclusions, peliosis hepatis, and cholangiomatous lesions were also encountered frequently in te livers.
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U2 - 10.1093/jnci/58.2.387
DO - 10.1093/jnci/58.2.387
M3 - Article
C2 - 189051
AN - SCOPUS:0017347866
SN - 0027-8874
VL - 58
SP - 387
EP - 392
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 2
ER -