Induction of specific protein tyrosine phosphatase transcripts during differentiation of mouse embryonal carcinoma (F9) cells

Kazuhide Tsuneizumi; Tsutomu Kume; Toshio Watanabe; Martijn F B G Gebbink; Matthew L. Thomas; Michio Oishi

doi:10.1016/0014-5793(94)00491-9

Induction of specific protein tyrosine phosphatase transcripts during differentiation of mouse embryonal carcinoma (F9) cells

Kazuhide Tsuneizumi, Tsutomu Kume, Toshio Watanabe, Martijn F B G Gebbink, Matthew L. Thomas, Michio Oishi^*

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We have investigated the pattern of PTPase transcript expression during in vitro differentiation of mouse embryonal carcinoma (F9) cells. While the transcripts of most PTPases were unchanged or undetected during embryonal differentiation induced by retinoic acid, several PTPase transcripts exhibited distinct patterns of induction. Mutant cells defective in differentiation did not display the induction of some of these PTPase transcripts. Interestingly, three out of the four PTPase transcripts induced were the same PTPase transcripts induced during in vitro erythroid differentiation of mouse erythroleukemia (MEL) cells [(1982) Biochem. Biophys. Res. Commun. 107, 1104-1109]. The possible role played by specific PTPases in cell differentiation is discussed.

Original language	English (US)
Pages (from-to)	9-12
Number of pages	4
Journal	FEBS Letters
Volume	347
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(94)00491-9
State	Published - Jun 20 1994

Keywords

Differentiation
Embryonal carcinoma cell
Protein tyrosine phosphatase

ASJC Scopus subject areas

Genetics
Molecular Biology
Biophysics
Structural Biology
Biochemistry
Cell Biology

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10.1016/0014-5793(94)00491-9

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title = "Induction of specific protein tyrosine phosphatase transcripts during differentiation of mouse embryonal carcinoma (F9) cells",

abstract = "We have investigated the pattern of PTPase transcript expression during in vitro differentiation of mouse embryonal carcinoma (F9) cells. While the transcripts of most PTPases were unchanged or undetected during embryonal differentiation induced by retinoic acid, several PTPase transcripts exhibited distinct patterns of induction. Mutant cells defective in differentiation did not display the induction of some of these PTPase transcripts. Interestingly, three out of the four PTPase transcripts induced were the same PTPase transcripts induced during in vitro erythroid differentiation of mouse erythroleukemia (MEL) cells [(1982) Biochem. Biophys. Res. Commun. 107, 1104-1109]. The possible role played by specific PTPases in cell differentiation is discussed.",

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AU - Tsuneizumi, Kazuhide

AU - Kume, Tsutomu

AU - Watanabe, Toshio

AU - Gebbink, Martijn F B G

AU - Thomas, Matthew L.

AU - Oishi, Michio

PY - 1994/6/20

Y1 - 1994/6/20

N2 - We have investigated the pattern of PTPase transcript expression during in vitro differentiation of mouse embryonal carcinoma (F9) cells. While the transcripts of most PTPases were unchanged or undetected during embryonal differentiation induced by retinoic acid, several PTPase transcripts exhibited distinct patterns of induction. Mutant cells defective in differentiation did not display the induction of some of these PTPase transcripts. Interestingly, three out of the four PTPase transcripts induced were the same PTPase transcripts induced during in vitro erythroid differentiation of mouse erythroleukemia (MEL) cells [(1982) Biochem. Biophys. Res. Commun. 107, 1104-1109]. The possible role played by specific PTPases in cell differentiation is discussed.

AB - We have investigated the pattern of PTPase transcript expression during in vitro differentiation of mouse embryonal carcinoma (F9) cells. While the transcripts of most PTPases were unchanged or undetected during embryonal differentiation induced by retinoic acid, several PTPase transcripts exhibited distinct patterns of induction. Mutant cells defective in differentiation did not display the induction of some of these PTPase transcripts. Interestingly, three out of the four PTPase transcripts induced were the same PTPase transcripts induced during in vitro erythroid differentiation of mouse erythroleukemia (MEL) cells [(1982) Biochem. Biophys. Res. Commun. 107, 1104-1109]. The possible role played by specific PTPases in cell differentiation is discussed.

KW - Differentiation

KW - Embryonal carcinoma cell

KW - Protein tyrosine phosphatase

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Induction of specific protein tyrosine phosphatase transcripts during differentiation of mouse embryonal carcinoma (F9) cells

Abstract

Keywords

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