Induction of specific protein tyrosine phosphatase transcripts during differentiation of mouse embryonal carcinoma (F9) cells

Kazuhide Tsuneizumi, Tsutomu Kume, Toshio Watanabe, Martijn F B G Gebbink, Matthew L. Thomas, Michio Oishi*

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We have investigated the pattern of PTPase transcript expression during in vitro differentiation of mouse embryonal carcinoma (F9) cells. While the transcripts of most PTPases were unchanged or undetected during embryonal differentiation induced by retinoic acid, several PTPase transcripts exhibited distinct patterns of induction. Mutant cells defective in differentiation did not display the induction of some of these PTPase transcripts. Interestingly, three out of the four PTPase transcripts induced were the same PTPase transcripts induced during in vitro erythroid differentiation of mouse erythroleukemia (MEL) cells [(1982) Biochem. Biophys. Res. Commun. 107, 1104-1109]. The possible role played by specific PTPases in cell differentiation is discussed.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalFEBS Letters
Volume347
Issue number1
DOIs
StatePublished - Jun 20 1994

Keywords

  • Differentiation
  • Embryonal carcinoma cell
  • Protein tyrosine phosphatase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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