TY - JOUR
T1 - Induction of the neural crest state
T2 - Control of stem cell attributes by gene regulatory, post-transcriptional and epigenetic interactions
AU - Prasad, Maneeshi S.
AU - Sauka-Spengler, Tatjana
AU - LaBonne, Carole
N1 - Funding Information:
The authors thank Elsy Buitrago Delgado, Keith Hultman, Kara Nordin and Ritika Giri for comments on the manuscript. We apologize for work that could not be included due to space constraints. Relevant work in the authors' labs is supported by NIH RO1CA114058 , RO1GM077288 and R21DE022150 (CL).
PY - 2012/6/1
Y1 - 2012/6/1
N2 - Neural crest cells are a population of multipotent stem cell-like progenitors that arise at the neural plate border in vertebrates, migrate extensively, and give rise to diverse derivatives such as melanocytes, craniofacial cartilage and bone, smooth muscle, peripheral and enteric neurons and glia. The neural crest gene regulatory network (NC-GRN) includes a number of key factors that are used reiteratively to control multiple steps in the development of neural crest cells, including the acquisition of stem cell attributes. It is therefore essential to understand the mechanisms that control the distinct functions of such reiteratively used factors in different cellular contexts. The context-dependent control of neural crest specification is achieved through combinatorial interaction with other factors, post-transcriptional and post-translational modifications, and the epigenetic status and chromatin state of target genes. Here we review the current understanding of the NC-GRN, including the role of the neural crest specifiers, their links to the control of "stemness," and their dynamic context-dependent regulation during the formation of neural crest progenitors.
AB - Neural crest cells are a population of multipotent stem cell-like progenitors that arise at the neural plate border in vertebrates, migrate extensively, and give rise to diverse derivatives such as melanocytes, craniofacial cartilage and bone, smooth muscle, peripheral and enteric neurons and glia. The neural crest gene regulatory network (NC-GRN) includes a number of key factors that are used reiteratively to control multiple steps in the development of neural crest cells, including the acquisition of stem cell attributes. It is therefore essential to understand the mechanisms that control the distinct functions of such reiteratively used factors in different cellular contexts. The context-dependent control of neural crest specification is achieved through combinatorial interaction with other factors, post-transcriptional and post-translational modifications, and the epigenetic status and chromatin state of target genes. Here we review the current understanding of the NC-GRN, including the role of the neural crest specifiers, their links to the control of "stemness," and their dynamic context-dependent regulation during the formation of neural crest progenitors.
KW - C-Myc
KW - Epigenetics
KW - Epithelial-mesenchymal transition
KW - Foxd3
KW - NC-GRN
KW - Neural crest
KW - Snail
KW - SoxE
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U2 - 10.1016/j.ydbio.2012.03.014
DO - 10.1016/j.ydbio.2012.03.014
M3 - Review article
C2 - 22583479
AN - SCOPUS:84860838210
VL - 366
SP - 10
EP - 21
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 1
ER -