Induction of tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitivity with hapten-modified lymphoid cells. II. Selective tolerance in F1 mice of T cell subsets recognizing 1-fluoro-2,4-dinitrobenzene associated with parental major histocompatibility complex antigens

P. J. Conlon, J. W. Moorhead, S. D. Miller, H. N. Claman

Research output: Contribution to journalArticle

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Abstract

F1 animals were tolerized to 1-fluoro-2,4-dinitrobenzene (DNFB) contact sensitivity with parentally derived, in vitro hapten-modified spleen cells. This tolerant state was found, upon adoptive transfer to naive parental strain recipients, to affect only that T cell subpopulation that recognized the parental haplotype of the cell used as the tolerogen, and did not inhibit the specific of the remaining T cell subset to confer immunity. This demonstrates that this tolerant state involves the inactivation of a cell required for the expression of contact sensitivity by recognizing DNFB in association with self major histocompatibility complex gene products.

Original languageEnglish (US)
Pages (from-to)959-964
Number of pages6
JournalJournal of Experimental Medicine
Volume151
Issue number4
DOIs
StatePublished - Jan 1 1980

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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