Ineffectiveness of aprotinin on psoralen-UVA-(PUVA)-induced erythema

E. Weintraub, D. P. West, L. M. Solomon

Research output: Contribution to journalArticlepeer-review

Abstract

Because bradykinin constitutes a possible candidate for mediation of topical 8-methoxypsoralen-UVA-(PUVA)-induced erythema, aprotinin (Trasylol), inhibitor of kallikrein and interrupter of the cascade leading to kinin production was assessed in guinea pigs. Response was assessed at 24, 48, and 72 hr after topical PUVA and there was no significant difference between normal saline and aprotinin by intradermal or intraperitoneal routes of administration. The results of this study indicate that intradermal and intraperitoneal aprotinin, in the dose and method tested, is not capable of significantly decreasing erythema induced by topical PUVA in guinea pigs.

Original languageEnglish (US)
Pages (from-to)527-529
Number of pages3
JournalJournal of Investigative Dermatology
Volume73
Issue number6
DOIs
StatePublished - 1979

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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