Infantile glaucoma in down's syndrome (Trisomy 21)

Elias I. Traboulsi*, Elliot Levine, Marilyn B. Mets, Edward S. Parelhoff, John F. O'Neill, Douglas E. Gaasterland

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

We examined five patients with Down's syndrome and bilateral infantile glaucoma. In the first few months of life four patients had large cloudy corneas, breaks in Descemet's membrane, increased intraocular pressure, photophobia, and tearing. In one patient the diagnosis was delayed until 3 1 2 years of age because of concomitant nasolacrimal duct obstruction. Two patients developed cataracts and retinal detachment and have undergone multiple surgical procedures. The clinical course in these two older patients suggests that coexistence of congenital glaucoma, severe myopia, and cataracts in patients with trisomy 21 strongly predisposes for the development of retinal detachment and poor visual outcome.

Original languageEnglish (US)
Pages (from-to)389-394
Number of pages6
JournalAmerican journal of ophthalmology
Volume105
Issue number4
DOIs
StatePublished - Apr 15 1988

ASJC Scopus subject areas

  • Ophthalmology

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