Infection and Alcoholic Liver Disease

Christine Chan, Josh Levitsky*

*Corresponding author for this work

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Acute and chronic alcohol use leads to an impaired immune response and dysregulated inflammatory state that contributes to a markedly increased risk of infection. Via shared mechanisms of immune-mediated injury, alcohol can alter the clinical course of viral infections such as hepatitis B, hepatitis C, and human immunodeficiency virus. These effects are most evident in patients with alcoholic hepatitis and cirrhosis. This article provides an overview of alcohol's effect on the immune system and contribution to the risks and outcomes of specific infectious diseases.

Original languageEnglish (US)
Pages (from-to)595-606
Number of pages12
JournalClinics in liver disease
Volume20
Issue number3
DOIs
StatePublished - Aug 1 2016

Fingerprint

Alcoholic Liver Diseases
Alcohols
Infection
Alcoholic Hepatitis
Alcoholic Liver Cirrhosis
Virus Diseases
Hepatitis C
Hepatitis B
Communicable Diseases
Immune System
HIV
Wounds and Injuries

Keywords

  • Alcoholic hepatitis
  • Cellular immunity
  • Cirrhosis
  • Infectious disease

ASJC Scopus subject areas

  • Hepatology

Cite this

Chan, Christine ; Levitsky, Josh. / Infection and Alcoholic Liver Disease. In: Clinics in liver disease. 2016 ; Vol. 20, No. 3. pp. 595-606.
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Infection and Alcoholic Liver Disease. / Chan, Christine; Levitsky, Josh.

In: Clinics in liver disease, Vol. 20, No. 3, 01.08.2016, p. 595-606.

Research output: Contribution to journalReview article

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AU - Chan, Christine

AU - Levitsky, Josh

PY - 2016/8/1

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N2 - Acute and chronic alcohol use leads to an impaired immune response and dysregulated inflammatory state that contributes to a markedly increased risk of infection. Via shared mechanisms of immune-mediated injury, alcohol can alter the clinical course of viral infections such as hepatitis B, hepatitis C, and human immunodeficiency virus. These effects are most evident in patients with alcoholic hepatitis and cirrhosis. This article provides an overview of alcohol's effect on the immune system and contribution to the risks and outcomes of specific infectious diseases.

AB - Acute and chronic alcohol use leads to an impaired immune response and dysregulated inflammatory state that contributes to a markedly increased risk of infection. Via shared mechanisms of immune-mediated injury, alcohol can alter the clinical course of viral infections such as hepatitis B, hepatitis C, and human immunodeficiency virus. These effects are most evident in patients with alcoholic hepatitis and cirrhosis. This article provides an overview of alcohol's effect on the immune system and contribution to the risks and outcomes of specific infectious diseases.

KW - Alcoholic hepatitis

KW - Cellular immunity

KW - Cirrhosis

KW - Infectious disease

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