Infection and Alcoholic Liver Disease

Christine Chan; Josh Levitsky

doi:10.1016/j.cld.2016.02.014

Infection and Alcoholic Liver Disease

Christine Chan, Josh Levitsky^*

^*Corresponding author for this work

Medicine, Hepatology Division

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Acute and chronic alcohol use leads to an impaired immune response and dysregulated inflammatory state that contributes to a markedly increased risk of infection. Via shared mechanisms of immune-mediated injury, alcohol can alter the clinical course of viral infections such as hepatitis B, hepatitis C, and human immunodeficiency virus. These effects are most evident in patients with alcoholic hepatitis and cirrhosis. This article provides an overview of alcohol's effect on the immune system and contribution to the risks and outcomes of specific infectious diseases.

Original language	English (US)
Pages (from-to)	595-606
Number of pages	12
Journal	Clinics in liver disease
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.cld.2016.02.014
State	Published - Aug 1 2016

Keywords

Alcoholic hepatitis
Cellular immunity
Cirrhosis
Infectious disease

ASJC Scopus subject areas

Hepatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cld.2016.02.014

Cite this

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title = "Infection and Alcoholic Liver Disease",

abstract = "Acute and chronic alcohol use leads to an impaired immune response and dysregulated inflammatory state that contributes to a markedly increased risk of infection. Via shared mechanisms of immune-mediated injury, alcohol can alter the clinical course of viral infections such as hepatitis B, hepatitis C, and human immunodeficiency virus. These effects are most evident in patients with alcoholic hepatitis and cirrhosis. This article provides an overview of alcohol's effect on the immune system and contribution to the risks and outcomes of specific infectious diseases.",

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AU - Levitsky, Josh

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N2 - Acute and chronic alcohol use leads to an impaired immune response and dysregulated inflammatory state that contributes to a markedly increased risk of infection. Via shared mechanisms of immune-mediated injury, alcohol can alter the clinical course of viral infections such as hepatitis B, hepatitis C, and human immunodeficiency virus. These effects are most evident in patients with alcoholic hepatitis and cirrhosis. This article provides an overview of alcohol's effect on the immune system and contribution to the risks and outcomes of specific infectious diseases.

AB - Acute and chronic alcohol use leads to an impaired immune response and dysregulated inflammatory state that contributes to a markedly increased risk of infection. Via shared mechanisms of immune-mediated injury, alcohol can alter the clinical course of viral infections such as hepatitis B, hepatitis C, and human immunodeficiency virus. These effects are most evident in patients with alcoholic hepatitis and cirrhosis. This article provides an overview of alcohol's effect on the immune system and contribution to the risks and outcomes of specific infectious diseases.

KW - Alcoholic hepatitis

KW - Cellular immunity

KW - Cirrhosis

KW - Infectious disease

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Infection and Alcoholic Liver Disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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