TY - JOUR
T1 - Infection of macrophage-like cells by Legionella species that have not been associated with disease
AU - O'Connell, William A.
AU - Dhand, Leena
AU - Cianciotto, Nicholas P.
PY - 1996
Y1 - 1996
N2 - We assessed the ability of Legionella species that have not been associated with disease to infect macrophage-like U937 cells. Two of fourteen species tested exhibited a 50% infective dose that was within 1 log unit of that of virulent L. pneumophila. Indeed, intracellular CFU of L. jamestowniensis and L. parisiensis increased 100-fold over a 72-h period. These data indicate that additional legionellae can flourish within phagocytes and therefore, can, if given the opportunity, cause disease.
AB - We assessed the ability of Legionella species that have not been associated with disease to infect macrophage-like U937 cells. Two of fourteen species tested exhibited a 50% infective dose that was within 1 log unit of that of virulent L. pneumophila. Indeed, intracellular CFU of L. jamestowniensis and L. parisiensis increased 100-fold over a 72-h period. These data indicate that additional legionellae can flourish within phagocytes and therefore, can, if given the opportunity, cause disease.
UR - http://www.scopus.com/inward/record.url?scp=0029838669&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029838669&partnerID=8YFLogxK
U2 - 10.1128/iai.64.10.4381-4384.1996
DO - 10.1128/iai.64.10.4381-4384.1996
M3 - Article
C2 - 8926117
AN - SCOPUS:0029838669
SN - 0019-9567
VL - 64
SP - 4381
EP - 4384
JO - Infection and Immunity
JF - Infection and Immunity
IS - 10
ER -
