Infection of macrophage-like cells by Legionella species that have not been associated with disease

William A. O'Connell, Leena Dhand, Nicholas P. Cianciotto*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

We assessed the ability of Legionella species that have not been associated with disease to infect macrophage-like U937 cells. Two of fourteen species tested exhibited a 50% infective dose that was within 1 log unit of that of virulent L. pneumophila. Indeed, intracellular CFU of L. jamestowniensis and L. parisiensis increased 100-fold over a 72-h period. These data indicate that additional legionellae can flourish within phagocytes and therefore, can, if given the opportunity, cause disease.

Original languageEnglish (US)
Pages (from-to)4381-4384
Number of pages4
JournalInfection and immunity
Volume64
Issue number10
DOIs
StatePublished - 1996

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Infection of macrophage-like cells by Legionella species that have not been associated with disease'. Together they form a unique fingerprint.

Cite this