Infection of mouse teratocarcinoma stem cells with influenza virus: Normal expression of proteins derived from spliced messenger RNAs

Sidney Strickland; Robert A. Lamb

doi:10.1016/0012-1606(83)90108-2

Infection of mouse teratocarcinoma stem cells with influenza virus: Normal expression of proteins derived from spliced messenger RNAs

Sidney Strickland^*, Robert A. Lamb

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Article › peer-review

Abstract

Mouse teratocarcinoma stem cells before and after induction of differentiation have been infected with influenza virus. This virus is able to infect the cells irrespective of the state of differentiation. In addition, viral-encoded proteins that are known to be translated from spliced messenger RNAs are produced in normal amounts in the infected cells, and this expression is also independent of differentiation. These results indicate that both the stem cells and their differentiated progeny can efficiently splice the precursor RNAs for these influenza virus messengers.

Original language	English (US)
Pages (from-to)	506-509
Number of pages	4
Journal	Developmental Biology
Volume	97
Issue number	2
DOIs	https://doi.org/10.1016/0012-1606(83)90108-2
State	Published - Jun 1983

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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10.1016/0012-1606(83)90108-2

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title = "Infection of mouse teratocarcinoma stem cells with influenza virus: Normal expression of proteins derived from spliced messenger RNAs",

abstract = "Mouse teratocarcinoma stem cells before and after induction of differentiation have been infected with influenza virus. This virus is able to infect the cells irrespective of the state of differentiation. In addition, viral-encoded proteins that are known to be translated from spliced messenger RNAs are produced in normal amounts in the infected cells, and this expression is also independent of differentiation. These results indicate that both the stem cells and their differentiated progeny can efficiently splice the precursor RNAs for these influenza virus messengers.",

author = "Sidney Strickland and Lamb, {Robert A.}",

note = "Funding Information: This work was supported by grants from the National Institutes of Health (HD-16078 and AI-18{\textquoteright}746), the American Cancer Society (CD-48). and the Whitehall Foundation. R.A.L. is an Irma T. Hirsch1 awardee, and S.S. and R.A.L. are Established Investigators of the American Heart Association.",

year = "1983",

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T1 - Infection of mouse teratocarcinoma stem cells with influenza virus

T2 - Normal expression of proteins derived from spliced messenger RNAs

AU - Strickland, Sidney

AU - Lamb, Robert A.

N1 - Funding Information: This work was supported by grants from the National Institutes of Health (HD-16078 and AI-18’746), the American Cancer Society (CD-48). and the Whitehall Foundation. R.A.L. is an Irma T. Hirsch1 awardee, and S.S. and R.A.L. are Established Investigators of the American Heart Association.

PY - 1983/6

Y1 - 1983/6

N2 - Mouse teratocarcinoma stem cells before and after induction of differentiation have been infected with influenza virus. This virus is able to infect the cells irrespective of the state of differentiation. In addition, viral-encoded proteins that are known to be translated from spliced messenger RNAs are produced in normal amounts in the infected cells, and this expression is also independent of differentiation. These results indicate that both the stem cells and their differentiated progeny can efficiently splice the precursor RNAs for these influenza virus messengers.

AB - Mouse teratocarcinoma stem cells before and after induction of differentiation have been infected with influenza virus. This virus is able to infect the cells irrespective of the state of differentiation. In addition, viral-encoded proteins that are known to be translated from spliced messenger RNAs are produced in normal amounts in the infected cells, and this expression is also independent of differentiation. These results indicate that both the stem cells and their differentiated progeny can efficiently splice the precursor RNAs for these influenza virus messengers.

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Infection of mouse teratocarcinoma stem cells with influenza virus: Normal expression of proteins derived from spliced messenger RNAs

Abstract

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