TY - JOUR
T1 - Infection with human immunodeficiency virus
T2 - Clinical manifestations and their relationship to immune deficiency. A report from the Multicenter AIDS cohort study
AU - Kaslow, R. A.
AU - Phair, J. P.
AU - Friedman, H. B.
AU - Lyter, D.
AU - Solomon, R. E.
AU - Dudley, J.
AU - Polk, B. F.
AU - Blackwelder, W.
PY - 1987/1/1
Y1 - 1987/1/1
N2 - In 1984 a large prospective study of gay and bisexual men was begun to elucidate the natural history of the human immunodeficiency virus (HIV) infection. At two successive semiannual examinations, clinical or hematologic abnormalities were found up to 13 times more often among HIV-seropositive men (n = 1611) than HIV-seronegative men (n = 2646). More than 30% of the seropositive participants had persistent generalized lymphadenopathy, independent of T-helper lymphocyte (CD4) counts and most other signs and symptoms. Other clinical manifestations such as thrush, anemia, thrombocytopenia, neutropenia, fever, and fatigue occurred with only slightly reduced CD4 counts (400 to 700/mm3) and appeared to increase exponentially with progressively lower counts. A simple systematically derived clinical index using these manifestations identified more than 70% of the seropositive men with significant T-helper cell depletion. This kind of clinical index may be useful for assessing groups of HIV-infected persons, especially those whose T-lymphocyte numbers and function cannot be readily measured.
AB - In 1984 a large prospective study of gay and bisexual men was begun to elucidate the natural history of the human immunodeficiency virus (HIV) infection. At two successive semiannual examinations, clinical or hematologic abnormalities were found up to 13 times more often among HIV-seropositive men (n = 1611) than HIV-seronegative men (n = 2646). More than 30% of the seropositive participants had persistent generalized lymphadenopathy, independent of T-helper lymphocyte (CD4) counts and most other signs and symptoms. Other clinical manifestations such as thrush, anemia, thrombocytopenia, neutropenia, fever, and fatigue occurred with only slightly reduced CD4 counts (400 to 700/mm3) and appeared to increase exponentially with progressively lower counts. A simple systematically derived clinical index using these manifestations identified more than 70% of the seropositive men with significant T-helper cell depletion. This kind of clinical index may be useful for assessing groups of HIV-infected persons, especially those whose T-lymphocyte numbers and function cannot be readily measured.
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U2 - 10.7326/0003-4819-107-4-474
DO - 10.7326/0003-4819-107-4-474
M3 - Article
C2 - 2957944
AN - SCOPUS:0023280613
SN - 0003-4819
VL - 107
SP - 474
EP - 480
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
IS - 4
ER -