Infections in Sickle-Cell Disease

G. X. Trimble, S. T. Shulman, E. A. Ayoub

Research output: Contribution to journalLetterpeer-review

2 Scopus citations


To the Editor: In their original article, “The Unusual Severity of Mycoplasmal Pneumonia in Children with Sickle-Cell Disease” (N Engl J Med 287:164, 1972), Shulman and his colleagues point out that patients with sickle-cell (SS) disease “are unusually susceptible to infection with the pneumococcus, salmonella and shigella.” They then go on to say, “Predisposition of these patients to infection with nonbacterial agents has not been reported.” It is not clear whether the authors were referring to a predisposition to pulmonary infection with nonbacterial agents or to systemic infections with nonbacterial agents. If it was the latter they had in.

Original languageEnglish (US)
Pages (from-to)669
Number of pages1
JournalNew England Journal of Medicine
Issue number13
StatePublished - Sep 28 1972

ASJC Scopus subject areas

  • General Medicine


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