Infectious Chronic Rhinosinusitis

Sumit Bose, Leslie C. Grammer, Anju T. Peters*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Chronic rhinosinusitis (CRS) is a persistent inflammatory disease that affects a multitude of people worldwide. The pathogenesis of CRS involves many factors including genetics, status of the sinonasal microbiome, infections, and environmental influences. Comorbidities associated with CRS include asthma, allergic rhinitis, bronchiectasis, and certain kinds of immunodeficiency. CRS can be divided into different subtypes based on endotypes and phenotypes. Infectious CRS is one such category. The etiology of infectious CRS is usually secondary to chronic bacterial infection that commonly begins with a viral upper respiratory tract infection. Humoral antibody deficiencies can underlie difficult-to-treat or recurrent CRS. Infectious CRS can be treated with antimicrobials, topical or oral corticosteroids, and nasal saline irrigations. Patients with CRS and humoral immunodeficiency may require an aggressive treatment approach including immunoglobulin replacement therapy. Despite advancements in the field of CRS, targeted therapies and reliable biomarkers are still lacking.

Original languageEnglish (US)
Pages (from-to)584-589
Number of pages6
JournalJournal of Allergy and Clinical Immunology: In Practice
Issue number4
StatePublished - Jul 1 2016


  • Bacterial
  • Exacerbation
  • Immunodeficiency
  • Infectious
  • Microbiome
  • Pathogenesis
  • Rhinosinusitis
  • Sinonasal

ASJC Scopus subject areas

  • Immunology and Allergy


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