TY - JOUR
T1 - Infectious disease transmission in solid organ transplantation
T2 - Donor evaluation, recipient risk, and outcomes of transmission
AU - White, Sarah L.
AU - Rawlinson, William
AU - Boan, Peter
AU - Sheppeard, Vicky
AU - Wong, Germaine
AU - Waller, Karen
AU - Opdam, Helen
AU - Kaldor, John
AU - Fink, Michael
AU - Verran, Deborah
AU - Webster, Angela
AU - Wyburn, Kate
AU - Grayson, Lindsay
AU - Glanville, Allan
AU - Cross, Nick
AU - Irish, Ashley
AU - Coates, Toby
AU - Griffin, Anthony
AU - Snell, Greg
AU - Alexander, Stephen I.
AU - Campbell, Scott
AU - Chadban, Steven
AU - Macdonald, Peter
AU - Manley, Paul
AU - Mehakovic, Eva
AU - Ramachandran, Vidya
AU - Mitchell, Alicia
AU - Ison, Michael
N1 - Publisher Copyright:
Copyright © 2018 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
PY - 2019/1
Y1 - 2019/1
N2 - In 2016, the Transplantation Society of Australia and New Zealand, with the support of the Australian Government Organ and Tissue authority, commissioned a literature review on the topic of infectious disease transmission from deceased donors to recipients of solid organ transplants. The purpose of this review was to synthesize evidence on transmission risks, diagnostic test characteristics, and recipient management to inform best-practice clinical guidelines. The final review, presented as a special supplement in Transplantation Direct, collates case reports of transmission events and other peer-reviewed literature, and summarizes current (as of June 2017) international guidelines on donor screening and recipient management. Of particular interest at the time of writing was how to maximize utilization of donors at increased risk for transmission of human immunodeficiency virus, hepatitis C virus, and hepatitis B virus, given the recent developments, including the availability of direct-acting antivirals for hepatitis C virus and improvements in donor screening technologies. The review also covers emerging risks associated with recent epidemics (eg, Zika virus) and the risk of transmission of nonendemic pathogens related to donor travel history or country of origin. Lastly, the implications for recipient consent of expanded utilization of donors at increased risk of blood-borne viral disease transmission are considered.
AB - In 2016, the Transplantation Society of Australia and New Zealand, with the support of the Australian Government Organ and Tissue authority, commissioned a literature review on the topic of infectious disease transmission from deceased donors to recipients of solid organ transplants. The purpose of this review was to synthesize evidence on transmission risks, diagnostic test characteristics, and recipient management to inform best-practice clinical guidelines. The final review, presented as a special supplement in Transplantation Direct, collates case reports of transmission events and other peer-reviewed literature, and summarizes current (as of June 2017) international guidelines on donor screening and recipient management. Of particular interest at the time of writing was how to maximize utilization of donors at increased risk for transmission of human immunodeficiency virus, hepatitis C virus, and hepatitis B virus, given the recent developments, including the availability of direct-acting antivirals for hepatitis C virus and improvements in donor screening technologies. The review also covers emerging risks associated with recent epidemics (eg, Zika virus) and the risk of transmission of nonendemic pathogens related to donor travel history or country of origin. Lastly, the implications for recipient consent of expanded utilization of donors at increased risk of blood-borne viral disease transmission are considered.
UR - http://www.scopus.com/inward/record.url?scp=85064169195&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064169195&partnerID=8YFLogxK
U2 - 10.1097/TXD.0000000000000852
DO - 10.1097/TXD.0000000000000852
M3 - Review article
C2 - 30656214
AN - SCOPUS:85064169195
SN - 2373-8731
VL - 5
JO - Transplantation Direct
JF - Transplantation Direct
IS - 1
M1 - e416
ER -
