Infectious Morbidity and All-cause Mortality of Infants HIV-exposed Uninfected Compared to Infants HIV-unexposed Uninfected in Botswana

Melanie M. Dubois; Jennifer Jao; Shan Sun; Justine Legbedze; Sara Schenkel; Nicholas Mmasa; Samuel W. Kgole; Gosego Masasa; Anna Ursula Happel; Saori C. Iwase; Roxanna Haghighat; Sikhulile Moyo; Tanvi S. Sharma; Paul T. Edlefsen; Danica Shao; Heather Jaspan; Kathleen M. Powis

doi:10.1097/INF.0000000000004603

Infectious Morbidity and All-cause Mortality of Infants HIV-exposed Uninfected Compared to Infants HIV-unexposed Uninfected in Botswana

Melanie M. Dubois^*, Jennifer Jao, Shan Sun, Justine Legbedze, Sara Schenkel, Nicholas Mmasa, Samuel W. Kgole, Gosego Masasa, Anna Ursula Happel, Saori C. Iwase, Roxanna Haghighat, Sikhulile Moyo, Tanvi S. Sharma, Paul T. Edlefsen, Danica Shao, Heather Jaspan, Kathleen M. Powis

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

Abstract

Some studies have reported increased infectious morbidity and all-cause mortality risk among infants HIV-exposed uninfected compared with infants HIV-unexposed uninfected. In a retrospective analysis of infants enrolled in the Botswana-based Tshilo Dikotla study, we found no difference in the prevalence of infectious hospitalizations or deaths from any cause in the first year of life by perinatal HIV exposure.

Original language	English (US)
Pages (from-to)	214-216
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	44
Issue number	3
DOIs	https://doi.org/10.1097/INF.0000000000004603
State	Published - Mar 1 2025

Funding

We thank the mothers and infants who participated in the Tshilo Dikotla study, as well as the Botswana Harvard Health Partnership, along with the clinical research team and lab staff. This publication was made possible with biostatistical support from the Harvard University Center for AIDS Research (CFAR), an NIH-funded program (P30 AI060354), which is supported by the following NIH cofunding and participating institutes and centers: NIAID, NCI, NICHD, NIDCR, NHLBI, NIDA, NIMH, NIA, NIDDK, NINR, NIMHD, FIC, and OAR. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Study funding was provided by R01DK109881 (Tshilo Dikotla: principal investigator (PI): J.J.) and R01AI142670 (Karabo: PI: K.M.P.). M.M.D. received salary support from NIAID T32 AI007433 (PI: Dr. Freedberg).

Keywords

HIV
infant HIV-exposed uninfected
infectious morbidity

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/INF.0000000000004603

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Dubois, M. M., Jao, J., Sun, S., Legbedze, J., Schenkel, S., Mmasa, N., Kgole, S. W., Masasa, G., Happel, A. U., Iwase, S. C., Haghighat, R., Moyo, S., Sharma, T. S., Edlefsen, P. T., Shao, D., Jaspan, H., & Powis, K. M. (2025). Infectious Morbidity and All-cause Mortality of Infants HIV-exposed Uninfected Compared to Infants HIV-unexposed Uninfected in Botswana. Pediatric Infectious Disease Journal, 44(3), 214-216. https://doi.org/10.1097/INF.0000000000004603

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Dubois, MM, Jao, J, Sun, S, Legbedze, J, Schenkel, S, Mmasa, N, Kgole, SW, Masasa, G, Happel, AU, Iwase, SC, Haghighat, R, Moyo, S, Sharma, TS, Edlefsen, PT, Shao, D, Jaspan, H & Powis, KM 2025, 'Infectious Morbidity and All-cause Mortality of Infants HIV-exposed Uninfected Compared to Infants HIV-unexposed Uninfected in Botswana', Pediatric Infectious Disease Journal, vol. 44, no. 3, pp. 214-216. https://doi.org/10.1097/INF.0000000000004603

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Infectious Morbidity and All-cause Mortality of Infants HIV-exposed Uninfected Compared to Infants HIV-unexposed Uninfected in Botswana

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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